Neuro-ophthalmologic manifestations of a paraneoplastic syndrome and testicular carcinoma

J. L. Bennett, Steven L. Galetta, L. P. Frohman, Z. Mourelatos, S. H. Gultekin, J. O. Dalmau, J. B. Posner

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Abstract

The authors report two patients with testicular cancer who exhibited supranuclear gaze disorders as a manifestation of a paraneo-plastic brainstem encephalomyelitis. In the first patient, neuro-ophthalmic dysfunction was accompanied by a prominent limbic encephalitis whereas in the second patient, an unusual, mixed pendular and jerk nystagmus was manifested. Neuroimaging revealed an enhancing hypothalamic mass in the first patient and was negative in the second. Blood from both patients contained an antibody previously reported in a patient with limbic encephalitis and testicular cancer.

Original languageEnglish (US)
Pages (from-to)864-867
Number of pages4
JournalNeurology
Volume52
Issue number4
StatePublished - Mar 10 1999

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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    Bennett, J. L., Galetta, S. L., Frohman, L. P., Mourelatos, Z., Gultekin, S. H., Dalmau, J. O., & Posner, J. B. (1999). Neuro-ophthalmologic manifestations of a paraneoplastic syndrome and testicular carcinoma. Neurology, 52(4), 864-867.