Neurobiology of Opioid Addiction

P. Tahsili-Fahadan, G. Aston-Jones

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Opioid addiction is a major medical and social problem worldwide. Chronic use of opioids causes long-term adaptations in the nervous system. These neuroadaptations underlie behavioral manifestations of opioid dependence and are thought to be important in the compulsive nature of drug taking, drug craving, and vulnerability to relapse during abstinence. In this article, we discuss the consequences of opioid use in a chronological manner from first drug encounters to addiction and relapse.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Behavioral Neuroscience
PublisherElsevier Inc.
Pages393-403
Number of pages11
ISBN (Electronic)9780080914558
ISBN (Print)9780080453965
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

Keywords

  • Addiction
  • Dependence
  • Dopamine
  • Extended amygdala
  • Glutamate
  • Heroin
  • Morphine
  • Norepinephrine
  • Opiate abuse
  • Opioid
  • Relapse
  • Reward
  • Synaptic plasticity
  • Tolerance
  • Withdrawal

Fingerprint Dive into the research topics of 'Neurobiology of Opioid Addiction'. Together they form a unique fingerprint.

Cite this