Neurobiology of Opioid Addiction

P. Tahsili-Fahadan, G. Aston-Jones

Research output: Chapter in Book/Report/Conference proceedingChapter


Opioid addiction is a major medical and social problem worldwide. Chronic use of opioids causes long-term adaptations in the nervous system. These neuroadaptations underlie behavioral manifestations of opioid dependence and are thought to be important in the compulsive nature of drug taking, drug craving, and vulnerability to relapse during abstinence. In this article, we discuss the consequences of opioid use in a chronological manner from first drug encounters to addiction and relapse.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Behavioral Neuroscience
PublisherElsevier Inc.
Number of pages11
ISBN (Electronic)9780080914558
ISBN (Print)9780080453965
StatePublished - Jan 1 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)


  • Addiction
  • Dependence
  • Dopamine
  • Extended amygdala
  • Glutamate
  • Heroin
  • Morphine
  • Norepinephrine
  • Opiate abuse
  • Opioid
  • Relapse
  • Reward
  • Synaptic plasticity
  • Tolerance
  • Withdrawal

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