Neurochemical and behavioral deficits consequent to expression of a dominant negative EphA5 receptor

A. K. Halladay, L. Tessarollo, R. Zhou, G. C. Wagner

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The Eph family tyrosine kinase receptors and their ligands have been linked to axon guidance and topographic mapping of the developing central nervous system. More specifically, the EphA5 receptor has been shown to play a role in development of hippocamposeptal, retinotectal and thalamocortical projections. Recently, a line of transgenic mice was developed which expresses a truncated EphA5 receptor lacking a functional tyrosine kinase domain. In a previous study, axonal tracing revealed that medial hippocampal axons in this strain projected laterally and ventrally away from their normal target area. In the current study, both transgenic and wild-type controls were evaluated in unconditioned (rotorod and locomotor activity) and conditioned (water maze and active avoidance) behavior tasks which tested hippocampal and striatal functioning. Compared to controls, the transgenic strain did not show differences in rotorod motor activity but did show a transient deficit in spatial navigation ability and a consistent impairment in active avoidance. The dominant-negative mutant receptor also resulted in a decrease in striatal dopamine and serotonin concentrations with no change in hippocampal monoamines. Collectively, these data suggest that animals expressing a truncated EphA5 receptor show deficits related to striatal functioning.

Original languageEnglish (US)
Pages (from-to)104-111
Number of pages8
JournalMolecular Brain Research
Issue number1-2
StatePublished - Apr 7 2004

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience


  • Behavior
  • Eph
  • Mice
  • Monoamines and behavior
  • Neural basis of behavior
  • Striatum
  • Transgenic


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