Neuronal and glial cells in the superficial layers of early postnatal mouse neocortex: Immunofluorescence observations

Norbert König; Melitta Schachner

doi:10.1016/0304-3940(81)90137-3

Neuronal and glial cells in the superficial layers of early postnatal mouse neocortex: Immunofluorescence observations

Norbert König, Melitta Schachner

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Sections of immature (postnatal day 5) mouse cerebral cortex were examined for several cell-type specific immunological markers. Glial fibrillary acidic (GFA) protein or vimentin were detected in astrocytic cell processes and - more rarely - cell bodies located in the superficial layers, but not within putative Cajal-Retzius cells (CRs). These cells did, however, react with cholera toxin, tetanus toxin and NS-4 antibodies. In agreement with previous ultrastructural observations, we conclude that CRs are neurons, or at least cells which display the basic characteristics of neurons.

Original language	English (US)
Pages (from-to)	227-231
Number of pages	5
Journal	Neuroscience Letters
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(81)90137-3
State	Published - Nov 4 1981
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

Keywords

Cajal-Retzius cells
immunohistology
mouse
neuronal markers

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10.1016/0304-3940(81)90137-3

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title = "Neuronal and glial cells in the superficial layers of early postnatal mouse neocortex: Immunofluorescence observations",

abstract = "Sections of immature (postnatal day 5) mouse cerebral cortex were examined for several cell-type specific immunological markers. Glial fibrillary acidic (GFA) protein or vimentin were detected in astrocytic cell processes and - more rarely - cell bodies located in the superficial layers, but not within putative Cajal-Retzius cells (CRs). These cells did, however, react with cholera toxin, tetanus toxin and NS-4 antibodies. In agreement with previous ultrastructural observations, we conclude that CRs are neurons, or at least cells which display the basic characteristics of neurons.",

keywords = "Cajal-Retzius cells, immunohistology, mouse, neuronal markers",

author = "Norbert K{\"o}nig and Melitta Schachner",

note = "Funding Information: The present work has been supported by grants from C.N.R.S. (ERA 187) and Deutsche Forschungsgemeinschaft (Scha 185/6). The authors are grateful to their colleagues L.F. Eng, W.W. Franke, E. Habermann and F. Rathjen for antibodies and toxins. They thank Mr. P. Sibleyras for his help in preparing the illustrations.",

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doi = "10.1016/0304-3940(81)90137-3",

language = "English (US)",

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pages = "227--231",

journal = "Neuroscience Letters",

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TY - JOUR

T1 - Neuronal and glial cells in the superficial layers of early postnatal mouse neocortex

T2 - Immunofluorescence observations

AU - König, Norbert

AU - Schachner, Melitta

N1 - Funding Information: The present work has been supported by grants from C.N.R.S. (ERA 187) and Deutsche Forschungsgemeinschaft (Scha 185/6). The authors are grateful to their colleagues L.F. Eng, W.W. Franke, E. Habermann and F. Rathjen for antibodies and toxins. They thank Mr. P. Sibleyras for his help in preparing the illustrations.

PY - 1981/11/4

Y1 - 1981/11/4

N2 - Sections of immature (postnatal day 5) mouse cerebral cortex were examined for several cell-type specific immunological markers. Glial fibrillary acidic (GFA) protein or vimentin were detected in astrocytic cell processes and - more rarely - cell bodies located in the superficial layers, but not within putative Cajal-Retzius cells (CRs). These cells did, however, react with cholera toxin, tetanus toxin and NS-4 antibodies. In agreement with previous ultrastructural observations, we conclude that CRs are neurons, or at least cells which display the basic characteristics of neurons.

AB - Sections of immature (postnatal day 5) mouse cerebral cortex were examined for several cell-type specific immunological markers. Glial fibrillary acidic (GFA) protein or vimentin were detected in astrocytic cell processes and - more rarely - cell bodies located in the superficial layers, but not within putative Cajal-Retzius cells (CRs). These cells did, however, react with cholera toxin, tetanus toxin and NS-4 antibodies. In agreement with previous ultrastructural observations, we conclude that CRs are neurons, or at least cells which display the basic characteristics of neurons.

KW - Cajal-Retzius cells

KW - immunohistology

KW - mouse

KW - neuronal markers

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SN - 0304-3940

VL - 26

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JO - Neuroscience Letters

JF - Neuroscience Letters

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ER -

Neuronal and glial cells in the superficial layers of early postnatal mouse neocortex: Immunofluorescence observations

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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