Neuronal Motility and Structure: Cdk5 Pathways

B. A. Samuels, L. H. Tsai

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Signaling pathways involving cyclin-dependent kinase 5 (Cdk5) are now well established as major regulators of cytoskeletal function during the neuronal migration program. When taken in combination with other signaling pathways, such as those involving Reelin, our understanding of the molecular mechanisms that orchestrate neuronal positioning and brain development is becoming more complete. This article details the phenotypes of mice with Cdk5 deficiencies and provides an overview of the known Cdk5 signaling pathways that mediate neuronal motility and axon guidance.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages8
ISBN (Print)9780080450469
StatePublished - 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


  • ActinAxon guidanceCell motilityCyclin-dependent kinase 5(Cdk5)CytoskeletonDoublecortinDyneinFocal adhesion kinaseLissencephalyMiller-Dieker syndromeNdel1 (Nudel)Neuronal migrationp35Reelin


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