Neuronal Motility and Structure: Cdk5 Pathways

B. A. Samuels; L. H. Tsai

doi:10.1016/B978-008045046-9.00716-6

Neuronal Motility and Structure: Cdk5 Pathways

B. A. Samuels, L. H. Tsai

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Signaling pathways involving cyclin-dependent kinase 5 (Cdk5) are now well established as major regulators of cytoskeletal function during the neuronal migration program. When taken in combination with other signaling pathways, such as those involving Reelin, our understanding of the molecular mechanisms that orchestrate neuronal positioning and brain development is becoming more complete. This article details the phenotypes of mice with Cdk5 deficiencies and provides an overview of the known Cdk5 signaling pathways that mediate neuronal motility and axon guidance.

Original language	English (US)
Title of host publication	Encyclopedia of Neuroscience
Publisher	Elsevier Ltd
Pages	703-710
Number of pages	8
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.00716-6
State	Published - 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

Keywords

ActinAxon guidanceCell motilityCyclin-dependent kinase 5(Cdk5)CytoskeletonDoublecortinDyneinFocal adhesion kinaseLissencephalyMiller-Dieker syndromeNdel1 (Nudel)Neuronal migrationp35Reelin

Access to Document

10.1016/B978-008045046-9.00716-6

Cite this

@inbook{cabcda8adabb45eb9b8eb00d2a6134ed,

title = "Neuronal Motility and Structure: Cdk5 Pathways",

abstract = "Signaling pathways involving cyclin-dependent kinase 5 (Cdk5) are now well established as major regulators of cytoskeletal function during the neuronal migration program. When taken in combination with other signaling pathways, such as those involving Reelin, our understanding of the molecular mechanisms that orchestrate neuronal positioning and brain development is becoming more complete. This article details the phenotypes of mice with Cdk5 deficiencies and provides an overview of the known Cdk5 signaling pathways that mediate neuronal motility and axon guidance.",

keywords = "ActinAxon guidanceCell motilityCyclin-dependent kinase 5(Cdk5)CytoskeletonDoublecortinDyneinFocal adhesion kinaseLissencephalyMiller-Dieker syndromeNdel1 (Nudel)Neuronal migrationp35Reelin",

author = "Samuels, {B. A.} and Tsai, {L. H.}",

year = "2010",

doi = "10.1016/B978-008045046-9.00716-6",

language = "English (US)",

isbn = "9780080450469",

pages = "703--710",

booktitle = "Encyclopedia of Neuroscience",

publisher = "Elsevier Ltd",

}

TY - CHAP

T1 - Neuronal Motility and Structure

T2 - Cdk5 Pathways

AU - Samuels, B. A.

AU - Tsai, L. H.

PY - 2010

Y1 - 2010

N2 - Signaling pathways involving cyclin-dependent kinase 5 (Cdk5) are now well established as major regulators of cytoskeletal function during the neuronal migration program. When taken in combination with other signaling pathways, such as those involving Reelin, our understanding of the molecular mechanisms that orchestrate neuronal positioning and brain development is becoming more complete. This article details the phenotypes of mice with Cdk5 deficiencies and provides an overview of the known Cdk5 signaling pathways that mediate neuronal motility and axon guidance.

AB - Signaling pathways involving cyclin-dependent kinase 5 (Cdk5) are now well established as major regulators of cytoskeletal function during the neuronal migration program. When taken in combination with other signaling pathways, such as those involving Reelin, our understanding of the molecular mechanisms that orchestrate neuronal positioning and brain development is becoming more complete. This article details the phenotypes of mice with Cdk5 deficiencies and provides an overview of the known Cdk5 signaling pathways that mediate neuronal motility and axon guidance.

KW - ActinAxon guidanceCell motilityCyclin-dependent kinase 5(Cdk5)CytoskeletonDoublecortinDyneinFocal adhesion kinaseLissencephalyMiller-Dieker syndromeNdel1 (Nudel)Neuronal migrationp35Reelin

UR - http://www.scopus.com/inward/record.url?scp=84882928446&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882928446&partnerID=8YFLogxK

U2 - 10.1016/B978-008045046-9.00716-6

DO - 10.1016/B978-008045046-9.00716-6

M3 - Chapter

AN - SCOPUS:84882928446

SN - 9780080450469

SP - 703

EP - 710

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd

ER -

Neuronal Motility and Structure: Cdk5 Pathways

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this