Neurons in accumbens subterritories of the rat: Phasic firing time- locked within seconds of intravenous cocaine self-infusion

Anthony J. Uzwiak, Francis X. Guyette, Mark O. West, Laura L. Peoples

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Individual neurons were recorded extracellularly in the nucleus accumbens (NAcc) of rats during cocaine self-administration sessions. NAcc neurons exhibited a variety of phasic changes in firing rate within the few seconds before and/or after cocaine self-infusion. Analysis of the topographical distribution of the phasic firing patterns showed that there were no differences between NAcc subterritories in the nature of phasic changes in firing exhibited by neurons in relation to cocaine self-infusion. However, the prevalence of phasic firing was lower in the border regions of the caudal shell and within the caudal shell itself relative to the remainder of the NAcc.

Original languageEnglish (US)
Pages (from-to)363-369
Number of pages7
JournalBrain research
Volume767
Issue number2
DOIs
StatePublished - Sep 5 1997

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • Cocaine
  • Core
  • Extracellular recording
  • Intravenous self- administration
  • Nucleus accumbens
  • Rat
  • Shell
  • Single neuron
  • Subterritory

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