Neuropsychiatric aspects of adult-onset Tay-Sachs disease: two case reports with several new findings

G. I. Hurowitz, J. M. Silver, M. F. Brin, D. T. Williams, W. G. Johnson

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Deficiency of hexosaminidase A causes the G(M2) gangliosidosis known as Tay-Sachs disease. It is now known that this condition has several late-onset variants that cause numerous neuropsychiatric disturbances. Early recognition is important because treatment with phenothiazines and heterocyclic antidepressants may worsen the course. The authors report two cases with several new findings, including prominent psychiatric symptoms without psychosis early in the course of the illness.

Original languageEnglish (US)
Pages (from-to)30-36
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume5
Issue number1
DOIs
StatePublished - 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Psychiatry and Mental health

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