Neurotrophins induce death of hippocampal neurons via the p75 receptor

Research output: Contribution to journalArticle

223 Citations (Scopus)

Abstract

Nerve growth factor (NGF) and related neurotrophins influence neuronal survival and differentiation via interactions with the trk family of receptors. Recent studies have demonstrated that neurotrophins may also induce cell death via the p75 receptor. The importance and generality of neurotrophin-induced death in the brain have not been defined but may play a critical role during development and in disease-associated neuronal death. Here we demonstrate for the first time that all four members of the neurotrophin family directly elicit the death of hippocampal neurons via the p75 receptor. The hippocampus is a complex structure with many different neuronal subpopulations, and signals that influence neuronal death during development may have a critical impact on the mature function of this structure. In these studies we show that each neurotrophin causes the death of hippocampal neurons expressing p75 but lacking the cognate trk receptor. Neurotrophin-induced neuronal death is mediated by activation of Jun kinase. These studies demonstrate that neurotrophins can regulate death as well as survival of CNS neurons.

Original languageEnglish (US)
Pages (from-to)6340-6346
Number of pages7
JournalJournal of Neuroscience
Volume20
Issue number17
StatePublished - Sep 1 2000
Externally publishedYes

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Nerve Growth Factors
Neurons
Brain Death
Nerve Growth Factor
Cause of Death
Hippocampus
Cell Death
Phosphotransferases

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

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title = "Neurotrophins induce death of hippocampal neurons via the p75 receptor",
abstract = "Nerve growth factor (NGF) and related neurotrophins influence neuronal survival and differentiation via interactions with the trk family of receptors. Recent studies have demonstrated that neurotrophins may also induce cell death via the p75 receptor. The importance and generality of neurotrophin-induced death in the brain have not been defined but may play a critical role during development and in disease-associated neuronal death. Here we demonstrate for the first time that all four members of the neurotrophin family directly elicit the death of hippocampal neurons via the p75 receptor. The hippocampus is a complex structure with many different neuronal subpopulations, and signals that influence neuronal death during development may have a critical impact on the mature function of this structure. In these studies we show that each neurotrophin causes the death of hippocampal neurons expressing p75 but lacking the cognate trk receptor. Neurotrophin-induced neuronal death is mediated by activation of Jun kinase. These studies demonstrate that neurotrophins can regulate death as well as survival of CNS neurons.",
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Neurotrophins induce death of hippocampal neurons via the p75 receptor. / Friedman, Wilma.

In: Journal of Neuroscience, Vol. 20, No. 17, 01.09.2000, p. 6340-6346.

Research output: Contribution to journalArticle

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