Neutrophilic and Pauci-immune Phenotypes in Severe Asthma

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41 Scopus citations


Although 2 T-helper type 2 inflammation evokes airway hyperresponsiveness and narrowing, neutrophilic or pauci-immune asthma accounts for significant asthma morbidity. Viruses, toxicants, environmental tobacco smoke exposure, and bacterial infections induce asthma exacerbations mediated by neutrophilic inflammation or by structural cell (pauci-immune) mechanisms. Therapeutic challenges exist in the management of neutrophilic and pauci-immune phenotypes because both syndromes manifest steroid insensitivity. The recognition that neutrophil subsets exist and their functions are unique poses exciting opportunities to develop precise therapies. The conventional thought to target neutrophil activation or migration globally may explain why current drug development in neutrophilic asthma remains challenging.

Original languageEnglish (US)
Pages (from-to)569-579
Number of pages11
JournalImmunology and Allergy Clinics of North America
Issue number3
StatePublished - Aug 1 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


  • Airway remodeling
  • Intrinsic asthma
  • Irreversible airway obstruction
  • Nonatopic asthma
  • Steroid insensitivity


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