New Therapy to Treat Spinal Cord Injury

Li Cai (Inventor), Misaal Patel (Inventor)

Research output: Innovation

Abstract

Treated SCI mice showed significant functional recovery


Invention Summary:

Spinal cord injury (SCI) results in permanent disruption to nervous system function. There is no effective treatment to promote recovery of motor function after spinal cord injury currently available on the market. Previous research for SCI treatment was focused on targeting either cell source (new neurons) for damage repair or glial scar (inhibition of astrogliosis) for axon regrowth. Although these efforts have laid important ground work in the field, translation to clinical practice has been limited due to the lack of significant functional recovery.

This invention disclosed a novel method to treat spinal cord injury via gene therapy. Rutgers scientists first discovered the important roles of a transcription factor Caix1 in neurogenesis and functional recovery after spinal cord injury. They found that Caix1 has the dual ability to promote neurogenesis and inhibit astrogliosis and improve functional recovery after spinal cord injury.


They demonstrated that injection of lentivirus-encoded Caix1 to the injury site after a spinal cord injury can increase the number of neural stem/neural progenitor cells and can improve the locomotor function of SCI mice as compared to mice receiving control lentivirus or lentivirus encoding a different transcription factor Nkx6.1 as a control. The figure above shows that the treated SCI mice had significant functional recovery.

Advantages:

  • Animal data showing that this therapy is effective
  • This method overcame multiple obstacles (e.g., immunorejection, long-term survival, and functional integration) of stem cell transplantation approach

Market Applications:

  • New approach to treat traumatic spinal cord injury
  • New approach to treat brain injury

Intellectual Property & Development Status:

Patent pending. Available for licensing or collaboration.

Original languageEnglish (US)
StatePublished - Feb 2019

Fingerprint

Spinal Cord Injuries
Lentivirus
Therapeutics
Neurogenesis
Transcription Factors
Intellectual Property
Recovery of Function
Stem Cell Transplantation
Licensure
Neuroglia
Genetic Therapy
Brain Injuries
Nervous System
Cicatrix
Axons
Stem Cells
Neurons
Injections
Wounds and Injuries

Cite this

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title = "New Therapy to Treat Spinal Cord Injury",
abstract = "Treated SCI mice showed significant functional recovery Invention Summary: Spinal cord injury (SCI) results in permanent disruption to nervous system function. There is no effective treatment to promote recovery of motor function after spinal cord injury currently available on the market. Previous research for SCI treatment was focused on targeting either cell source (new neurons) for damage repair or glial scar (inhibition of astrogliosis) for axon regrowth. Although these efforts have laid important ground work in the field, translation to clinical practice has been limited due to the lack of significant functional recovery. This invention disclosed a novel method to treat spinal cord injury via gene therapy. Rutgers scientists first discovered the important roles of a transcription factor Caix1 in neurogenesis and functional recovery after spinal cord injury. They found that Caix1 has the dual ability to promote neurogenesis and inhibit astrogliosis and improve functional recovery after spinal cord injury. They demonstrated that injection of lentivirus-encoded Caix1 to the injury site after a spinal cord injury can increase the number of neural stem/neural progenitor cells and can improve the locomotor function of SCI mice as compared to mice receiving control lentivirus or lentivirus encoding a different transcription factor Nkx6.1 as a control. The figure above shows that the treated SCI mice had significant functional recovery. Advantages: Animal data showing that this therapy is effective This method overcame multiple obstacles (e.g., immunorejection, long-term survival, and functional integration) of stem cell transplantation approach Market Applications: New approach to treat traumatic spinal cord injury New approach to treat brain injury Intellectual Property & Development Status: Patent pending. Available for licensing or collaboration.",
author = "Li Cai and Misaal Patel",
year = "2019",
month = "2",
language = "English (US)",
type = "Patent",

}

New Therapy to Treat Spinal Cord Injury. / Cai, Li (Inventor); Patel, Misaal (Inventor).

Research output: Innovation

TY - PAT

T1 - New Therapy to Treat Spinal Cord Injury

AU - Cai, Li

AU - Patel, Misaal

PY - 2019/2

Y1 - 2019/2

N2 - Treated SCI mice showed significant functional recovery Invention Summary: Spinal cord injury (SCI) results in permanent disruption to nervous system function. There is no effective treatment to promote recovery of motor function after spinal cord injury currently available on the market. Previous research for SCI treatment was focused on targeting either cell source (new neurons) for damage repair or glial scar (inhibition of astrogliosis) for axon regrowth. Although these efforts have laid important ground work in the field, translation to clinical practice has been limited due to the lack of significant functional recovery. This invention disclosed a novel method to treat spinal cord injury via gene therapy. Rutgers scientists first discovered the important roles of a transcription factor Caix1 in neurogenesis and functional recovery after spinal cord injury. They found that Caix1 has the dual ability to promote neurogenesis and inhibit astrogliosis and improve functional recovery after spinal cord injury. They demonstrated that injection of lentivirus-encoded Caix1 to the injury site after a spinal cord injury can increase the number of neural stem/neural progenitor cells and can improve the locomotor function of SCI mice as compared to mice receiving control lentivirus or lentivirus encoding a different transcription factor Nkx6.1 as a control. The figure above shows that the treated SCI mice had significant functional recovery. Advantages: Animal data showing that this therapy is effective This method overcame multiple obstacles (e.g., immunorejection, long-term survival, and functional integration) of stem cell transplantation approach Market Applications: New approach to treat traumatic spinal cord injury New approach to treat brain injury Intellectual Property & Development Status: Patent pending. Available for licensing or collaboration.

AB - Treated SCI mice showed significant functional recovery Invention Summary: Spinal cord injury (SCI) results in permanent disruption to nervous system function. There is no effective treatment to promote recovery of motor function after spinal cord injury currently available on the market. Previous research for SCI treatment was focused on targeting either cell source (new neurons) for damage repair or glial scar (inhibition of astrogliosis) for axon regrowth. Although these efforts have laid important ground work in the field, translation to clinical practice has been limited due to the lack of significant functional recovery. This invention disclosed a novel method to treat spinal cord injury via gene therapy. Rutgers scientists first discovered the important roles of a transcription factor Caix1 in neurogenesis and functional recovery after spinal cord injury. They found that Caix1 has the dual ability to promote neurogenesis and inhibit astrogliosis and improve functional recovery after spinal cord injury. They demonstrated that injection of lentivirus-encoded Caix1 to the injury site after a spinal cord injury can increase the number of neural stem/neural progenitor cells and can improve the locomotor function of SCI mice as compared to mice receiving control lentivirus or lentivirus encoding a different transcription factor Nkx6.1 as a control. The figure above shows that the treated SCI mice had significant functional recovery. Advantages: Animal data showing that this therapy is effective This method overcame multiple obstacles (e.g., immunorejection, long-term survival, and functional integration) of stem cell transplantation approach Market Applications: New approach to treat traumatic spinal cord injury New approach to treat brain injury Intellectual Property & Development Status: Patent pending. Available for licensing or collaboration.

UR - http://rutgers.technologypublisher.com/tech/New_Therapy_to_Treat_Spinal_Cord_Injury

M3 - Innovation

ER -

Cai L, Patel M, inventors. New Therapy to Treat Spinal Cord Injury. 2019 Feb.