NF-κB: Key mediator of inflammation-associated cancer

Dara Ditsworth, Wei Xing Zong

Research output: Contribution to journalShort surveypeer-review

59 Scopus citations


The NF-κB family of transcription factors, well-known for regulating immune and inflammatory responses, has recently been identified as a molecular link between chronic inflammation and cancer. Using distinct models of inflammation-associated cancer, three recent reports now show the importance of NF-κB in promoting cancer progression during inflammation (Greten et al., Cell 2004, 118:285-96; Luo et al., Cancer Cell 2004, 6:297-305, Pikarsky et al., Nature 2004, 431:461-6). Results from these studies suggest that NF-κB exerts its oncogenic effects in both tumor cells and in the tumor microenvironment, promoting the survival of premalignant epithelial cells while also stimulating release of pro-inflammatory mediators from activated macrophages that promote tumor growth.

Original languageEnglish (US)
Pages (from-to)1214-1216
Number of pages3
JournalCancer Biology and Therapy
Issue number12
StatePublished - Dec 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research


  • Cancer
  • Inflammation
  • NF-κB


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