Nitric oxide, S-Nitrosation, and endothelial permeability

Walter N. Durán, Annie V. Beuve, Fabiola A. Sánchez

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

S-Nitrosation is rapidly emerging as a regulatory mechanism in vascular biology, with particular importance in the onset of hyperpermeability induced by pro-inflammatory agents. This review focuses on the role of endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) in regulating S-Nitrosation of adherens junction proteins. We discuss evidence for translocation of eNOS, via caveolae, to the cytosol and analyze the significance of eNOS location for S-Nitrosation and onset of endothelial hyperpermeability to macromolecules.

Original languageEnglish (US)
Pages (from-to)819-826
Number of pages8
JournalIUBMB Life
Volume65
Issue number10
DOIs
StatePublished - Oct 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

Keywords

  • S-Nitrosation
  • VE-cadherin
  • adherens junction proteins
  • endothelial nitric oxide synthase
  • endothelial permeability
  • endothelium
  • microvascular permeability
  • nitric oxide
  • p120-catenin
  • regulation of inflammatory hyperpermeability

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