No conventional function for the conventional kinesin?

Virgil Muresan, Zoia Muresan

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

A paper by DeGiorgis et al. (DeGiorgis JA, Petukhova TA, Evans TA, Reese TS. Kinesin-3 is an organelle motor in the squid giant axon. Traffic 2008; DOI: 10.1111/j.1600-0854.2008.00809.x) in this issue of Traffic reports on the identification and function of a second squid kinesin, a kinesin-3 motor. As expected, the newly discovered motor associates with axoplasmic organelles in situ and powers motility along microtubules of vesicles isolated from squid axoplasm. Less expected was the finding that kinesin-3 may be the predominant motor for anterograde organelle movement in the squid axon, which challenges the so far undisputed view that this function is fulfilled by the conventional kinesin, kinesin-1. These novel findings let us wonder what the real function of kinesin-1 - the most abundant motor in squid axons - actually is.

Original languageEnglish (US)
Pages (from-to)1823-1827
Number of pages5
JournalTraffic
Volume9
Issue number11
DOIs
StatePublished - Oct 20 2008

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All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Keywords

  • Axonal transport
  • Kinesin-1
  • Kinesin-3
  • Microtubule transport
  • Squid giant axon
  • Vesicle transport

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