Abstract
A paper by DeGiorgis et al. (DeGiorgis JA, Petukhova TA, Evans TA, Reese TS. Kinesin-3 is an organelle motor in the squid giant axon. Traffic 2008; DOI: 10.1111/j.1600-0854.2008.00809.x) in this issue of Traffic reports on the identification and function of a second squid kinesin, a kinesin-3 motor. As expected, the newly discovered motor associates with axoplasmic organelles in situ and powers motility along microtubules of vesicles isolated from squid axoplasm. Less expected was the finding that kinesin-3 may be the predominant motor for anterograde organelle movement in the squid axon, which challenges the so far undisputed view that this function is fulfilled by the conventional kinesin, kinesin-1. These novel findings let us wonder what the real function of kinesin-1 - the most abundant motor in squid axons - actually is.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1823-1827 |
| Number of pages | 5 |
| Journal | Traffic |
| Volume | 9 |
| Issue number | 11 |
| DOIs | |
| State | Published - 2008 |
All Science Journal Classification (ASJC) codes
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology
Keywords
- Axonal transport
- Kinesin-1
- Kinesin-3
- Microtubule transport
- Squid giant axon
- Vesicle transport
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