No effect of prolonged corticosterone over-exposure on NCAM, SGK1, and RGS4 mRNA expression in rat hippocampus

Neeltje G. van Gemert; Els van Riel; Onno C. Meijer; Susanne Fehr; Melitta Schachner; Marian Joëls

doi:10.1016/j.brainres.2006.03.083

No effect of prolonged corticosterone over-exposure on NCAM, SGK1, and RGS4 mRNA expression in rat hippocampus

Neeltje G. van Gemert, Els van Riel, Onno C. Meijer, Susanne Fehr, Melitta Schachner, Marian Joëls

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Prolonged over-exposure of rats to corticosterone attenuates 5-HT_1A-receptor-mediated responses in hippocampal CA1 cells through an unknown mechanism, not involving downregulation of 5-HT_1A receptor expression. We here tested if corticosterone changes 5-HT_1A receptor function indirectly, by altering hippocampal mRNA expression of NCAM, SGK1, or RGS4, which all modulate 5-HT_1A receptor function. We found that the expression of none of these candidates was affected by corticosterone treatment.

Original language	English (US)
Pages (from-to)	161-166
Number of pages	6
Journal	Brain research
Volume	1093
Issue number	1
DOIs	https://doi.org/10.1016/j.brainres.2006.03.083
State	Published - Jun 6 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Keywords

Corticosterone
Hippocampus
Neural cell adhesion molecule
Rat
Regulator of G-protein signaling
Serum- and glucocorticoid-regulated kinase

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abstract = "Prolonged over-exposure of rats to corticosterone attenuates 5-HT1A-receptor-mediated responses in hippocampal CA1 cells through an unknown mechanism, not involving downregulation of 5-HT1A receptor expression. We here tested if corticosterone changes 5-HT1A receptor function indirectly, by altering hippocampal mRNA expression of NCAM, SGK1, or RGS4, which all modulate 5-HT1A receptor function. We found that the expression of none of these candidates was affected by corticosterone treatment.",

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AU - van Gemert, Neeltje G.

AU - van Riel, Els

AU - Meijer, Onno C.

AU - Fehr, Susanne

AU - Schachner, Melitta

AU - Joëls, Marian

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