No effect of prolonged corticosterone over-exposure on NCAM, SGK1, and RGS4 mRNA expression in rat hippocampus

Neeltje G. van Gemert, Els van Riel, Onno C. Meijer, Susanne Fehr, Melitta Schachner, Marian Joëls

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Prolonged over-exposure of rats to corticosterone attenuates 5-HT1A-receptor-mediated responses in hippocampal CA1 cells through an unknown mechanism, not involving downregulation of 5-HT1A receptor expression. We here tested if corticosterone changes 5-HT1A receptor function indirectly, by altering hippocampal mRNA expression of NCAM, SGK1, or RGS4, which all modulate 5-HT1A receptor function. We found that the expression of none of these candidates was affected by corticosterone treatment.

Original languageEnglish (US)
Pages (from-to)161-166
Number of pages6
JournalBrain research
Volume1093
Issue number1
DOIs
StatePublished - Jun 6 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • Corticosterone
  • Hippocampus
  • Neural cell adhesion molecule
  • Rat
  • Regulator of G-protein signaling
  • Serum- and glucocorticoid-regulated kinase

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