Prolonged over-exposure of rats to corticosterone attenuates 5-HT1A-receptor-mediated responses in hippocampal CA1 cells through an unknown mechanism, not involving downregulation of 5-HT1A receptor expression. We here tested if corticosterone changes 5-HT1A receptor function indirectly, by altering hippocampal mRNA expression of NCAM, SGK1, or RGS4, which all modulate 5-HT1A receptor function. We found that the expression of none of these candidates was affected by corticosterone treatment.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Clinical Neurology
- Developmental Biology
- Neural cell adhesion molecule
- Regulator of G-protein signaling
- Serum- and glucocorticoid-regulated kinase