Noncoding RNAs and Gene Silencing

Mikel Zaratiegui, Danielle V. Irvine, Robert A. Martienssen

Research output: Contribution to journalReview articlepeer-review

311 Scopus citations


Noncoding RNA has long been proposed to control gene expression via sequence-specific interactions with regulatory regions. Here, we review the role of noncoding RNA in heterochromatic silencing and in the silencing of transposable elements (TEs), unpaired DNA in meiosis, and developmentally excised DNA. The role of cotranscriptional processing by RNA interference and by other mechanisms is discussed, as well as parallels with RNA silencing in imprinting, paramutation, polycomb silencing, and X inactivation. Interactions with regulatory sequences may well occur, but at the RNA rather than at the DNA level.

Original languageEnglish (US)
Pages (from-to)763-776
Number of pages14
Issue number4
StatePublished - Feb 23 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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