NONINVASIVE MECHANICAL ASSESSMENT OF CONNECTIVE TISSUE DISORDERS.

Satish Kalath, Petros Tsipouras, Frederick H. Silver

Research output: Contribution to conferencePaperpeer-review

Abstract

To understand the changes in the mechanical properties of the aorta with age and due to inherited connective tissue disorders (CTD) several standard parameters were measured at the root of the aorta noninvasively. These parameters included end-diastolic and end-systolic aortic root diameter, wall thickness, and systolic and diastolic blood pressure. Based on these measurements several parameters were calculated, namely, percentage variation in diameter (PVD), pressure-strain elastic modulus (Ep), systolic circumferential modulus (Eo), systolic radial modulus (Er), and pulse wave velocity (C). Echocardiographic data from 35 patients of 9 different families (ages 4 to 75) with osteogenesis imperfecta, and 50 normal subjects (ages 12 to 65) were obtained to evaluate the mechanical properties of the aortic root in vivo. Control subjects were excluded if they had a history of CTD, heart disease, hypertension, abnormal EKG, obesity, or abnormal or technically insufficient echocardiogram. Measurements were made with ADR Ultrasound equipment using M-mode and 2D-mode with a 3. 0-MHz transducer.

Original languageEnglish (US)
Pages1-4
Number of pages4
StatePublished - 1985

All Science Journal Classification (ASJC) codes

  • Bioengineering

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