Nonthermal irreversible electroporation: Fundamentals, applications, and challenges

Alexander Golberg, Martin L. Yarmush

Research output: Contribution to journalReview articlepeer-review

168 Scopus citations


Tissue ablation is an essential procedure for the treatment of many diseases. In the last decade, a nonthermal tissue ablation using intensive pulsed electric fields, called nonthermal irreversible electroporation (NTIRE), has rapidly emerged. The exact mechanisms responsible for cell death by NTIRE, however, are currently unknown. Nevertheless, the technique's remarkable ability to ablate tissue in the proximity of larger blood vessels, to preserve tissue architecture, short procedure duration, and shortened postoperative recovery period rapidly moved NTIRE from bench to bed side. This work provides an overview on the development of NTIRE, its current state-of-the-art, challenges, and future needs.

Original languageEnglish (US)
Pages (from-to)707-714
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Issue number3
StatePublished - 2013

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering


  • Irreversible electroporation
  • Minimally invasive surgery
  • Nonthermal ablation
  • Pulsed electric fields


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