Noradrenergic modulation of midbrain dopamine cell firing elicited by stimulation of the locus coeruleus in the rat

J. Grenhoff, M. Nisell, S. Ferré, G. Aston-Jones, T. H. Svensson

Research output: Contribution to journalArticle

245 Scopus citations

Abstract

Electrical stimulation techniques were employed in the chloral hydrate anaesthetized male rat to evaluate if the pontine noradrenergic nucleus locus coeruleus can influence the activity of midbrain dopamine neurons in the ventral tegmental area and zona compacta, substantia nigra. Single-pulse locus coeruleus stimulation evoked an excitation, followed by an inhibition, of the electrical activity of single midbrain dopamine neurons. Neither of these responses were observed in animals pretreated with reserpine, implicating noradrenaline as a mediator. The α1-adrenoceptor antagonist prazosin decreased the excitation, while other adrenoceptor antagonists were without general effect. Burst-type stimulation produced only a more long-lasting inhibition. The influence from the locus coeruleus on midbrain dopamine neurons could be important in behavioural situations involving novelty and reward, and might also be of importance for the actions of psychotropic drugs.

Original languageEnglish (US)
Pages (from-to)11-25
Number of pages15
JournalJournal of Neural Transmission
Volume93
Issue number1
DOIs
StatePublished - Feb 1 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Keywords

  • Alpha-1-adrenoceptor
  • prazosin
  • single cell recording
  • substantia nigra
  • ventral tegmental area

Fingerprint Dive into the research topics of 'Noradrenergic modulation of midbrain dopamine cell firing elicited by stimulation of the locus coeruleus in the rat'. Together they form a unique fingerprint.

  • Cite this