Novel 4,4-bis(trifluoromethyl) imidazolines as stereospecific and orally active acyl CoA: Cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents

George A. Boswell, Hui Yin Li, Indawari Delucca, Jeffrey T. Billheimer, Spencer Drummond, Peter Gillies, Candy Robinson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A new class of very potent, systemically-active ACAT inhibitors based on a 4,4-bis(trifluoromethyl)imidazoline ring has been discovered. Compound 6 and its R-enantiomer 6a exhibited very potent oral activities in lowering the serum cholesterol in the animals.

Original languageEnglish (US)
Pages (from-to)885-888
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number7
DOIs
StatePublished - Apr 9 1996
Externally publishedYes

Fingerprint

Anticholesteremic Agents
Sterol O-Acyltransferase
Imidazolines
Enantiomers
Animals
Cholesterol
Serum

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Boswell, George A. ; Li, Hui Yin ; Delucca, Indawari ; Billheimer, Jeffrey T. ; Drummond, Spencer ; Gillies, Peter ; Robinson, Candy. / Novel 4,4-bis(trifluoromethyl) imidazolines as stereospecific and orally active acyl CoA : Cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents. In: Bioorganic and Medicinal Chemistry Letters. 1996 ; Vol. 6, No. 7. pp. 885-888.
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Novel 4,4-bis(trifluoromethyl) imidazolines as stereospecific and orally active acyl CoA : Cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents. / Boswell, George A.; Li, Hui Yin; Delucca, Indawari; Billheimer, Jeffrey T.; Drummond, Spencer; Gillies, Peter; Robinson, Candy.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 6, No. 7, 09.04.1996, p. 885-888.

Research output: Contribution to journalArticle

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