Novel chemotherapy approaches for cervical cancer

Sujana Movva, Lorna Rodriguez, Hugo Arias-Pulido, Claire Verschraegen

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations

Abstract

Cancer of the cervix is the second most common malignancy amongwomenworldwide.The last 20 years have lead to numerous advances in the medical management of locally advanced cervical cancer, including preventive vaccination, chemoradiation, and neoadjuvant chemotherapy.The treatment of metastatic disease is palliative at best. Platinum-based chemotherapy remains the standard of care for inoperable patients who have recurrent disease. However, because most patients initially receive concomitant platinum-based therapy with radiation, many recurrent tumors are refractory to platinum.The use of novel therapeutic approaches targeted to the carcinogenic processes that leads to the ontogenesis of cervical cancer should be promoted in clinical studies to improve patient outcomes.

Original languageEnglish (US)
Pages (from-to)3166-3180
Number of pages15
JournalCancer
Volume115
Issue number14
DOIs
StatePublished - 2009

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Adaptor proteins
  • Drug therapy
  • Epidermal growth factor receptor
  • Uterine cervical cancer

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