Novel inhibitors of the high-affinity l-proline transporter as potential therapeutic agents for the treatment of cognitive disorders

G. Greg Zipp, Joseph Barbosa, Michael A. Green, Kristen M. Terranova, Cynthia Fink, Xuan Chuan Yu, Amr Nouraldeen, Alan Wilson, Katerina Savelieva, Thomas H. Lanthorn, S. David Kimball

Research output: Contribution to journalArticle

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Abstract

The incidence of cognitive disorders such as Alzheimer's disease continues to increase unabated. While cures for such diseases have eluded investigators, progress is being made on alleviating certain symptoms of these diseases. Mouse knockouts of the proline transporter (PROT), a high affinity Na +/Cl--dependent transporter, indicated its potential as a novel therapeutic target for cognition improvement. Herein we report our investigation into a novel class of PROT inhibitors.

Original languageEnglish (US)
Pages (from-to)3886-3890
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number16
DOIs
StatePublished - Aug 15 2014

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Keywords

  • Acyl piperazine
  • Alzheimer's disease
  • Dimentia
  • Inhibitor
  • Proline transporter

Cite this

Zipp, G. G., Barbosa, J., Green, M. A., Terranova, K. M., Fink, C., Yu, X. C., Nouraldeen, A., Wilson, A., Savelieva, K., Lanthorn, T. H., & David Kimball, S. (2014). Novel inhibitors of the high-affinity l-proline transporter as potential therapeutic agents for the treatment of cognitive disorders. Bioorganic and Medicinal Chemistry Letters, 24(16), 3886-3890. https://doi.org/10.1016/j.bmcl.2014.06.049