The prevalence of diabetes throughout the world continues to increase and has become a major health issue. Recently there have been several reports of inhibitors directed toward the sodium-dependent glucose cotransporter 2 (SGLT2) as a method of maintaining glucose homeostasis in diabetic patients. Herein we report the discovery of the novel O-xyloside 7c that inhibits SGLT2 in vitro and urinary glucose reabsorption in vivo.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of medicinal chemistry|
|State||Published - Oct 22 2009|
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Drug Discovery