Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes

Nicole C. Goodwin; Ross Mabon; Bryce A. Harrison; Melanie K. Shadoan; Zheng Y. Almstead; Yiling Xie; Jason Healy; Lindsey M. Buhring; Christopher M. DaCosta; Jennifer Bardenhagen; Faika Mseeh; Qingyun Liu; Amr Nouraldeen; Alan G.E. Wilson; S. David Kimball; David R. Powell; David B. Rawlins

doi:10.1021/jm900951n

Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes

Nicole C. Goodwin, Ross Mabon, Bryce A. Harrison, Melanie K. Shadoan, Zheng Y. Almstead, Yiling Xie, Jason Healy, Lindsey M. Buhring, Christopher M. DaCosta, Jennifer Bardenhagen, Faika Mseeh, Qingyun Liu, Amr Nouraldeen, Alan G.E. Wilson, S. David Kimball, David R. Powell, David B. Rawlins

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68 Scopus citations

Abstract

The prevalence of diabetes throughout the world continues to increase and has become a major health issue. Recently there have been several reports of inhibitors directed toward the sodium-dependent glucose cotransporter 2 (SGLT2) as a method of maintaining glucose homeostasis in diabetic patients. Herein we report the discovery of the novel O-xyloside 7c that inhibits SGLT2 in vitro and urinary glucose reabsorption in vivo.

Original language	English (US)
Pages (from-to)	6201-6204
Number of pages	4
Journal	Journal of medicinal chemistry
Volume	52
Issue number	20
DOIs	https://doi.org/10.1021/jm900951n
State	Published - Oct 22 2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery

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Goodwin, N. C., Mabon, R., Harrison, B. A., Shadoan, M. K., Almstead, Z. Y., Xie, Y., Healy, J., Buhring, L. M., DaCosta, C. M., Bardenhagen, J., Mseeh, F., Liu, Q., Nouraldeen, A., Wilson, A. G. E., Kimball, S. D., Powell, D. R., & Rawlins, D. B. (2009). Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. Journal of medicinal chemistry, 52(20), 6201-6204. https://doi.org/10.1021/jm900951n

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title = "Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes",

abstract = "The prevalence of diabetes throughout the world continues to increase and has become a major health issue. Recently there have been several reports of inhibitors directed toward the sodium-dependent glucose cotransporter 2 (SGLT2) as a method of maintaining glucose homeostasis in diabetic patients. Herein we report the discovery of the novel O-xyloside 7c that inhibits SGLT2 in vitro and urinary glucose reabsorption in vivo.",

author = "Goodwin, {Nicole C.} and Ross Mabon and Harrison, {Bryce A.} and Shadoan, {Melanie K.} and Almstead, {Zheng Y.} and Yiling Xie and Jason Healy and Buhring, {Lindsey M.} and DaCosta, {Christopher M.} and Jennifer Bardenhagen and Faika Mseeh and Qingyun Liu and Amr Nouraldeen and Wilson, {Alan G.E.} and Kimball, {S. David} and Powell, {David R.} and Rawlins, {David B.}",

year = "2009",

month = oct,

day = "22",

doi = "10.1021/jm900951n",

language = "English (US)",

volume = "52",

pages = "6201--6204",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

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Goodwin, NC, Mabon, R, Harrison, BA, Shadoan, MK, Almstead, ZY, Xie, Y, Healy, J, Buhring, LM, DaCosta, CM, Bardenhagen, J, Mseeh, F, Liu, Q, Nouraldeen, A, Wilson, AGE, Kimball, SD, Powell, DR & Rawlins, DB 2009, 'Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes', Journal of medicinal chemistry, vol. 52, no. 20, pp. 6201-6204. https://doi.org/10.1021/jm900951n

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T1 - Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes

AU - Goodwin, Nicole C.

AU - Mabon, Ross

AU - Harrison, Bryce A.

AU - Shadoan, Melanie K.

AU - Almstead, Zheng Y.

AU - Xie, Yiling

AU - Healy, Jason

AU - Buhring, Lindsey M.

AU - DaCosta, Christopher M.

AU - Bardenhagen, Jennifer

AU - Mseeh, Faika

AU - Liu, Qingyun

AU - Nouraldeen, Amr

AU - Wilson, Alan G.E.

AU - Kimball, S. David

AU - Powell, David R.

AU - Rawlins, David B.

PY - 2009/10/22

Y1 - 2009/10/22

N2 - The prevalence of diabetes throughout the world continues to increase and has become a major health issue. Recently there have been several reports of inhibitors directed toward the sodium-dependent glucose cotransporter 2 (SGLT2) as a method of maintaining glucose homeostasis in diabetic patients. Herein we report the discovery of the novel O-xyloside 7c that inhibits SGLT2 in vitro and urinary glucose reabsorption in vivo.

AB - The prevalence of diabetes throughout the world continues to increase and has become a major health issue. Recently there have been several reports of inhibitors directed toward the sodium-dependent glucose cotransporter 2 (SGLT2) as a method of maintaining glucose homeostasis in diabetic patients. Herein we report the discovery of the novel O-xyloside 7c that inhibits SGLT2 in vitro and urinary glucose reabsorption in vivo.

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JO - Journal of Medicinal Chemistry

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IS - 20

ER -

Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes

Abstract

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