Novel quantitative tools for engineering analysis of hepatocyte cultures used in bioartificial liver systems

Marianthi Ierapetritou, N. Sharma, Martin Yarmush

Research output: Contribution to journalArticlepeer-review

Abstract

Study of hepatic metabolism is important in the context of basic biology, disease diagnosis and several biotechnological applications such as development of bioartificial support systems. In the current paper, we have utilized mathematical programming techniques to optimize the biochemical environment of hepatocyte cultures towards a desired effect of increased albumin and urea synthesis. Also, we have obtained a set of solutions corresponding to different objectives in the metabolic framework. These studies demonstrate an initial step towards generating a systematic approach to hepatocyte cultures and towards optimizing different parameters for an extracorporeal device based on real-time conditions.

Original languageEnglish (US)
Pages (from-to)1057-1062
Number of pages6
JournalComputer Aided Chemical Engineering
Volume18
Issue numberC
DOIs
StatePublished - Dec 1 2004

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Computer Science Applications

Keywords

  • hepatocytes
  • linear programming optimization
  • metabolic flux analysis

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