TY - JOUR
T1 - Novel RNA polymerase inhibitor found in soil extracts provides hope for future antibacterial drugs
AU - Ebright, Richard H.
N1 - Funding Information:
Research support was from National Institutes of Health (GM041376, AI104660, AI109713). The interviewee has research and patent filings on antibacterial targets, methods and compositions of matter. The interviewee has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Publisher Copyright:
© 2017 2017 Future Science Ltd.
PY - 2017/10
Y1 - 2017/10
N2 - Richard H Ebright talks to Rachel Coleby, Commissioning Editor: Ebright is at Rutgers University (New Brunswick, NJ, USA), where he performs research on the structure, mechanism, and regulation of bacterial transcription and on antibacterial drug discovery targeting bacterial transcription. He has received research awards, including the Searle Scholar Award, the Walter J Johnson Prize, the Schering-Plough Award of the American Society for Biochemistry and Molecular Biology, the Waksman Award of the Theobold Smith Society, the MERIT Award of the National Institutes of Health, and membership in the American Academy of Arts and Science. He has more than 130 publications in peer-reviewed journals and more than 30 issued and pending patents.
AB - Richard H Ebright talks to Rachel Coleby, Commissioning Editor: Ebright is at Rutgers University (New Brunswick, NJ, USA), where he performs research on the structure, mechanism, and regulation of bacterial transcription and on antibacterial drug discovery targeting bacterial transcription. He has received research awards, including the Searle Scholar Award, the Walter J Johnson Prize, the Schering-Plough Award of the American Society for Biochemistry and Molecular Biology, the Waksman Award of the Theobold Smith Society, the MERIT Award of the National Institutes of Health, and membership in the American Academy of Arts and Science. He has more than 130 publications in peer-reviewed journals and more than 30 issued and pending patents.
KW - RNA polymerase
KW - RNA polymerase inhibitors
KW - antibacterial agents
KW - antibacterial resistance
KW - antibiotics
KW - drug discovery
KW - microbial-extract screening
KW - nucleoside-analog inhibitors
KW - pseudouridimycin (PUM)
KW - rifampin
UR - http://www.scopus.com/inward/record.url?scp=85034665365&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85034665365&partnerID=8YFLogxK
U2 - 10.4155/fmc-2017-0188
DO - 10.4155/fmc-2017-0188
M3 - Review article
C2 - 29076390
AN - SCOPUS:85034665365
VL - 9
SP - 1857
EP - 1861
JO - Future Medicinal Chemistry
JF - Future Medicinal Chemistry
SN - 1756-8919
IS - 16
ER -