Novel RNA polymerase inhibitor found in soil extracts provides hope for future antibacterial drugs

Research output: Contribution to journalReview articlepeer-review

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Abstract

Richard H Ebright talks to Rachel Coleby, Commissioning Editor: Ebright is at Rutgers University (New Brunswick, NJ, USA), where he performs research on the structure, mechanism, and regulation of bacterial transcription and on antibacterial drug discovery targeting bacterial transcription. He has received research awards, including the Searle Scholar Award, the Walter J Johnson Prize, the Schering-Plough Award of the American Society for Biochemistry and Molecular Biology, the Waksman Award of the Theobold Smith Society, the MERIT Award of the National Institutes of Health, and membership in the American Academy of Arts and Science. He has more than 130 publications in peer-reviewed journals and more than 30 issued and pending patents.

Original languageEnglish (US)
Pages (from-to)1857-1861
Number of pages5
JournalFuture Medicinal Chemistry
Volume9
Issue number16
DOIs
StatePublished - Oct 2017

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

Keywords

  • RNA polymerase
  • RNA polymerase inhibitors
  • antibacterial agents
  • antibacterial resistance
  • antibiotics
  • drug discovery
  • microbial-extract screening
  • nucleoside-analog inhibitors
  • pseudouridimycin (PUM)
  • rifampin

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