Novel Synergistic Treatment of Ethanol Withdrawal Seizures in Rats with Dopamine and Serotonin Agonists

Yehudith Mirovsky, Yi Lung Yu, George C. Wagner, Anna Sekowski, Melissa Goldberg, Hans Fisher

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

A recent observation in this laboratory of a simultaneous increase in striatal dopamine and a decrease in serotonin in ethanol‐dependent rats during ethanol withdrawal prompted studies with combined dopaminergic + serotoninergic agonists to stop withdrawal seizures. Amphetamine (2 mg/kg) + fenfluramine (8 mg/kg) given jointly, but not separately, prevented ethanol withdrawal seizures as effectively as benzodiazepines (chlordiazepoxide), the current drugs of choice. The combination of amphetamine and fenfluramine, unlike chlordiazepoxide, significantly reduced intake of ethanol during and immediately following ethanol withdrawal.

Original languageEnglish (US)
Pages (from-to)160-163
Number of pages4
JournalAlcoholism: Clinical and Experimental Research
Volume19
Issue number1
DOIs
StatePublished - Feb 1995

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Keywords

  • Alcohol Withdrawal
  • Dopamine
  • Ethanol
  • Seizures
  • Serotonin

Fingerprint

Dive into the research topics of 'Novel Synergistic Treatment of Ethanol Withdrawal Seizures in Rats with Dopamine and Serotonin Agonists'. Together they form a unique fingerprint.

Cite this