Novelty-induced behavioral traits correlate with numbers of brainstem noradrenergic neurons and septal cholinergic neurons in C57BL/6J mice

Yuliya Tereshchenko, Joerg Brandewiede, Melitta Schachner, Andrey Irintchev, Fabio Morellini

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

It is generally accepted that different brain regions regulate specific behavioral responses and that structural alterations in these regions may affect behavior. We investigated whether inter-individual variability in novelty-induced behaviors in C57BL/6J mice correlates with numbers of noradrenergic neurons in the locus coeruleus and cholinergic neurons in the septum. We found that exploration of new stimuli correlated negatively with numbers of noradrenergic neurons, whereas anxiety correlated positively with numbers of cholinergic neurons. The observed correlations suggest physiologically plausible links between structure and function and indicate that precise morphological estimates can be predictive for behavioral responses.

Original languageEnglish (US)
Pages (from-to)280-284
Number of pages5
JournalBehavioural Brain Research
Volume191
Issue number2
DOIs
StatePublished - Aug 22 2008

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Keywords

  • Anxiety
  • Cholinergic
  • Exploration
  • Locus coeruleus
  • Morphology
  • Noradrenergic
  • Septum

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