Now, swing your partner! 3D-domain switching of WASP activates Arp2/3 complex

Sarah E. Hitchcock-DeGregori

doi:10.1038/nsb0803-583

Now, swing your partner! 3D-domain switching of WASP activates Arp2/3 complex

Sarah E. Hitchcock-DeGregori

RWJ-Pathology-PISC

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

Abstract

Structural and functional analysis of WASP family cell signaling proteins shows that the same residues that are sequestered upon GTPase binding in the autoinhibited state are involved in binding to and activating Arp2/3 complex, WASP's downstream partner in the signaling cascade.

Original language	English (US)
Pages (from-to)	583-584
Number of pages	2
Journal	Nature Structural Biology
Volume	10
Issue number	8
DOIs	https://doi.org/10.1038/nsb0803-583
State	Published - Aug 1 2003

All Science Journal Classification (ASJC) codes

Structural Biology
Biochemistry
Genetics

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title = "Now, swing your partner! 3D-domain switching of WASP activates Arp2/3 complex",

abstract = "Structural and functional analysis of WASP family cell signaling proteins shows that the same residues that are sequestered upon GTPase binding in the autoinhibited state are involved in binding to and activating Arp2/3 complex, WASP's downstream partner in the signaling cascade.",

author = "Hitchcock-DeGregori, {Sarah E.}",

year = "2003",

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doi = "10.1038/nsb0803-583",

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journal = "Nature Structural and Molecular Biology",

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AU - Hitchcock-DeGregori, Sarah E.

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N2 - Structural and functional analysis of WASP family cell signaling proteins shows that the same residues that are sequestered upon GTPase binding in the autoinhibited state are involved in binding to and activating Arp2/3 complex, WASP's downstream partner in the signaling cascade.

AB - Structural and functional analysis of WASP family cell signaling proteins shows that the same residues that are sequestered upon GTPase binding in the autoinhibited state are involved in binding to and activating Arp2/3 complex, WASP's downstream partner in the signaling cascade.

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U2 - 10.1038/nsb0803-583

DO - 10.1038/nsb0803-583

M3 - Short survey

C2 - 12886288

AN - SCOPUS:0041622693

VL - 10

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JO - Nature Structural and Molecular Biology

JF - Nature Structural and Molecular Biology

SN - 1545-9993

IS - 8

ER -

Now, swing your partner! 3D-domain switching of WASP activates Arp2/3 complex

Abstract

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