Nr-CAM

A cell adhesion molecule with ligand and receptor functions

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Nr-CAM Ng-CAM-related cell adhesion molecule) is expressed only in the nervous system on a subset of neurons and non-neuronal cells, including floor-plate cells in the spinal cord and Schwann cells. It is a member of the immunoglobulin (Ig) superfamily and can bind by a homophilic mechanism but its heterophilic interactions may be of greater biological significance. Nr-CAM functions as a neuronal receptor for neurite growth-promoting stimuli provided by contactin/F11, neurofascin, and RPTPβ. In addition, by binding to neuronal receptors such as axonin-1, it can modulate axonal guidance, Nr-CAM can also interact laterally with contactin/F11 within the plasma membrane in the form of a complex that may transmit signals to regulate axonal growth. This review summarizes the structure and expression of Nr-CAM and discusses its potential functions as a ligand and as a receptor during neural development.

Original languageEnglish (US)
Pages (from-to)423-428
Number of pages6
JournalCell And Tissue Research
Volume290
Issue number2
DOIs
StatePublished - Nov 13 1997
Externally publishedYes

Fingerprint

Contactins
Cell Adhesion Molecules
Computer aided manufacturing
Neuron-Glia Cell Adhesion Molecules
Contactin 2
Ligands
Schwann Cells
Sensory Receptor Cells
Neurites
Growth
Nervous System
Immunoglobulins
Spinal Cord
Cell Membrane
Neurons
Neurology
Cell membranes
Cells

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Clinical Biochemistry
  • Anatomy

Cite this

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abstract = "Nr-CAM Ng-CAM-related cell adhesion molecule) is expressed only in the nervous system on a subset of neurons and non-neuronal cells, including floor-plate cells in the spinal cord and Schwann cells. It is a member of the immunoglobulin (Ig) superfamily and can bind by a homophilic mechanism but its heterophilic interactions may be of greater biological significance. Nr-CAM functions as a neuronal receptor for neurite growth-promoting stimuli provided by contactin/F11, neurofascin, and RPTPβ. In addition, by binding to neuronal receptors such as axonin-1, it can modulate axonal guidance, Nr-CAM can also interact laterally with contactin/F11 within the plasma membrane in the form of a complex that may transmit signals to regulate axonal growth. This review summarizes the structure and expression of Nr-CAM and discusses its potential functions as a ligand and as a receptor during neural development.",
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Nr-CAM : A cell adhesion molecule with ligand and receptor functions. / Grumet, Martin.

In: Cell And Tissue Research, Vol. 290, No. 2, 13.11.1997, p. 423-428.

Research output: Contribution to journalArticle

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