Nrf2-target approaches in cancer chemoprevention mediated by dietary phytochemicals

Francisco Fuentes, Limin Shu, Jong Hun Lee, Zheng Yuan Su, Kyeong Ryoon Lee, Ah-Ng Kong

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Cancer chemoprevention with natural phytochemical compounds is an emerging strategy to prevent, impede, delay, or cure cancer. This chapter reviews the basic methods used to study the cancer chemopreventive potential of dietary phytochemicals acting by activating the transcriptional factor, nuclear factor-erythroid 2-related factor 2 (Nrf2 or NFE2L2), a basic-region leucine zipper (bZIP) transcription factor that regulates the expression of many phase II detoxifying/antioxidant enzymes. The Nrf2-target approaches in cancer chemoprevention comprise different methods including examining the Nrf2 signaling pathway, Nrf2-deficient tumor mouse models, pharmacokinetics (PK)/pharmacodynamics (PD) assessment, and epigenetic regulation.

Original languageEnglish (US)
Title of host publicationCancer Prevention
Subtitle of host publicationDietary Factors and Pharmacology
EditorsAnn M. Bode, Zigang Dong
Pages53-83
Number of pages31
DOIs
StatePublished - Jan 13 2014

Publication series

NameMethods in Pharmacology and Toxicology
ISSN (Print)1557-2153
ISSN (Electronic)1940-6053

Fingerprint

Chemoprevention
Phytochemicals
Neoplasms
Basic-Leucine Zipper Transcription Factors
Epigenomics
Pharmacokinetics
Antioxidants
Enzymes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Keywords

  • Cancer chemoprevention
  • Epigenetics
  • Nrf2
  • Nrf2-deficient mouse models
  • Pharmacodynamics
  • Pharmacokinetics

Cite this

Fuentes, F., Shu, L., Lee, J. H., Su, Z. Y., Lee, K. R., & Kong, A-N. (2014). Nrf2-target approaches in cancer chemoprevention mediated by dietary phytochemicals. In A. M. Bode, & Z. Dong (Eds.), Cancer Prevention: Dietary Factors and Pharmacology (pp. 53-83). (Methods in Pharmacology and Toxicology). https://doi.org/10.1007/978-1-4614-9227-6-3
Fuentes, Francisco ; Shu, Limin ; Lee, Jong Hun ; Su, Zheng Yuan ; Lee, Kyeong Ryoon ; Kong, Ah-Ng. / Nrf2-target approaches in cancer chemoprevention mediated by dietary phytochemicals. Cancer Prevention: Dietary Factors and Pharmacology. editor / Ann M. Bode ; Zigang Dong. 2014. pp. 53-83 (Methods in Pharmacology and Toxicology).
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Fuentes, F, Shu, L, Lee, JH, Su, ZY, Lee, KR & Kong, A-N 2014, Nrf2-target approaches in cancer chemoprevention mediated by dietary phytochemicals. in AM Bode & Z Dong (eds), Cancer Prevention: Dietary Factors and Pharmacology. Methods in Pharmacology and Toxicology, pp. 53-83. https://doi.org/10.1007/978-1-4614-9227-6-3

Nrf2-target approaches in cancer chemoprevention mediated by dietary phytochemicals. / Fuentes, Francisco; Shu, Limin; Lee, Jong Hun; Su, Zheng Yuan; Lee, Kyeong Ryoon; Kong, Ah-Ng.

Cancer Prevention: Dietary Factors and Pharmacology. ed. / Ann M. Bode; Zigang Dong. 2014. p. 53-83 (Methods in Pharmacology and Toxicology).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Fuentes F, Shu L, Lee JH, Su ZY, Lee KR, Kong A-N. Nrf2-target approaches in cancer chemoprevention mediated by dietary phytochemicals. In Bode AM, Dong Z, editors, Cancer Prevention: Dietary Factors and Pharmacology. 2014. p. 53-83. (Methods in Pharmacology and Toxicology). https://doi.org/10.1007/978-1-4614-9227-6-3