NS-4 (nervous system antigen-4), a cell surface antigen of developing and adult mouse brain and sperm

Melitta Schachner, Kathleen A. Wortham, Louvenia D. Carter, Jonathan K. Chaffee

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


When rabbits are injected with particulate fractions of cerebellum from 4-day-old C57BL 6J mice, an antiserum is produced that is cytotoxic for single-cell suspensions from cerebellum. After several absorptions with nonnervous system-derived tissues (liver, spleen, kidney, thymocytes) this heterologous antiserum reacts only with tissue from the developing and adult nervous system and sperm from vas deferens and epididymis. This antigen or set of antigens is present in neuroectodermally derived tissues at all ages tested: 12-day-old embryos and 12-month-old adults being the earliest and latest stages, respectively. The antigen is expressed not only on cerebellum but also on all parts of the normal central nervous system tested including retina. It is demonstrable on a murine medulloepithelioma and to a lesser degree on glioblastoma and ependymoblastoma but not on glioma G26, ependymoblastoma EPA and neuroblastoma C1300. The antigen is found in all mouse strains tested ( C57BL 6J, ICR, BALB cJ, A J and ( C57BL 6J × C3H HeJ) F1 hybrid) and in rat.

Original languageEnglish (US)
Pages (from-to)313-325
Number of pages13
JournalDevelopmental Biology
Issue number2
StatePublished - Jun 1975
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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