Nuclear SOD1 in Growth Control, Oxidative Stress Response, Amyotrophic Lateral Sclerosis, and Cancer

Joyce Xu, Xiaoyang Su, Stephen Burley, X. F.Steven Zheng

Research output: Contribution to journalReview articlepeer-review

Abstract

SOD1 is the major superoxide dismutase responsible for catalyzing dismutation of superoxide to hydrogen peroxide and molecular oxygen. It is well known as an essential antioxidant enzyme for maintaining cellular redox homeostasis. SOD1 dysregulation has been associated with many diseases, including amyotrophic lateral sclerosis (ALS), cancer, accelerated aging, and age-related diseases. Recent studies also revealed that SOD1 can serve as a regulatory protein in cell signaling, transcription, and ribosome biogenesis. Notably, SOD1 is localized in the nucleus under both normal and pathological conditions, contributing to oxidative stress response and growth control. Moreover, increasing evidence points to the importance of nuclear SOD1 in the pathogenesis of ALS and cancer.

Original languageEnglish (US)
Article number427
JournalAntioxidants
Volume11
Issue number2
DOIs
StatePublished - Feb 2022

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Keywords

  • Amyotrophic lateral sclerosis (ALS)
  • Cancer
  • Cell signaling
  • Reactive oxidative species (ROS)
  • Ribosome biogenesis
  • Superoxide dismutase 1 (SOD1)
  • Transcription

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