Nucleic acid biotechnology

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Driven by advances in the acquisition of genetic sequence information and the ability to manipulate small quantities of nucleic acid, a number of technologies are emerging that exploit nucleic acids for research, diagnostic, and therapeutic utility. In this review, we cover three technologies based on nucleic acids - DNA microarrays, antisense technology, and gene therapy - that are especially promising and may make a substantial impact in the laboratory and in the clinic during the coming years. For each of these areas, an overview of the current status and applications is provided, followed by a discussion of critical issues and challenges to be faced for further advancement of the technology; an emphasis is placed on quantitative and engineering aspects.

Original languageEnglish (US)
Pages (from-to)265-297
Number of pages33
JournalAnnual Review of Biomedical Engineering
Issue number1
StatePublished - 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomedical Engineering


  • Antisense
  • DNA microarrays
  • Functional genomics
  • Gene therapy


Dive into the research topics of 'Nucleic acid biotechnology'. Together they form a unique fingerprint.

Cite this