O-glycoside orientation is an essential aspect of base J recognition by the kinetoplastid DNA-binding protein JBP1

Rajesh K. Grover; Stephanie J.K. Pond; Qizhi Cui; Prem Subramaniam; David A. Case; David P. Millar; Paul Wentworth

doi:10.1002/anie.200604635

O-glycoside orientation is an essential aspect of base J recognition by the kinetoplastid DNA-binding protein JBP1

Rajesh K. Grover, Stephanie J.K. Pond, Qizhi Cui, Prem Subramaniam, David A. Case, David P. Millar, Paul Wentworth

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A binding edge? Comparison of dissociation constants and molecular-dynamics snapshots of a panel of synthetic telomeric double-stranded DNA sequences containing HMdU O-glycosides has revealed that the DNA-binding protein of kinetoplastids, such as Leishmania and Trypanosoma, JBP1, recognizes a critical edge-on conformation of the pyranosyl ring of base J. If this conformation is perturbed, JBP1 binding is dramatically reduced.(Chemical Equation Presented).

Original language	English (US)
Pages (from-to)	2839-2843
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	16
DOIs	https://doi.org/10.1002/anie.200604635
State	Published - 2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

Keywords

DNA
Glycosides
Molecular dynamics
Molecular recognition

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title = "O-glycoside orientation is an essential aspect of base J recognition by the kinetoplastid DNA-binding protein JBP1",

abstract = "A binding edge? Comparison of dissociation constants and molecular-dynamics snapshots of a panel of synthetic telomeric double-stranded DNA sequences containing HMdU O-glycosides has revealed that the DNA-binding protein of kinetoplastids, such as Leishmania and Trypanosoma, JBP1, recognizes a critical edge-on conformation of the pyranosyl ring of base J. If this conformation is perturbed, JBP1 binding is dramatically reduced.(Chemical Equation Presented).",

keywords = "DNA, Glycosides, Molecular dynamics, Molecular recognition",

author = "Grover, {Rajesh K.} and Pond, {Stephanie J.K.} and Qizhi Cui and Prem Subramaniam and Case, {David A.} and Millar, {David P.} and Paul Wentworth",

year = "2007",

doi = "10.1002/anie.200604635",

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volume = "46",

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T1 - O-glycoside orientation is an essential aspect of base J recognition by the kinetoplastid DNA-binding protein JBP1

AU - Grover, Rajesh K.

AU - Pond, Stephanie J.K.

AU - Cui, Qizhi

AU - Subramaniam, Prem

AU - Case, David A.

AU - Millar, David P.

AU - Wentworth, Paul

PY - 2007

Y1 - 2007

N2 - A binding edge? Comparison of dissociation constants and molecular-dynamics snapshots of a panel of synthetic telomeric double-stranded DNA sequences containing HMdU O-glycosides has revealed that the DNA-binding protein of kinetoplastids, such as Leishmania and Trypanosoma, JBP1, recognizes a critical edge-on conformation of the pyranosyl ring of base J. If this conformation is perturbed, JBP1 binding is dramatically reduced.(Chemical Equation Presented).

AB - A binding edge? Comparison of dissociation constants and molecular-dynamics snapshots of a panel of synthetic telomeric double-stranded DNA sequences containing HMdU O-glycosides has revealed that the DNA-binding protein of kinetoplastids, such as Leishmania and Trypanosoma, JBP1, recognizes a critical edge-on conformation of the pyranosyl ring of base J. If this conformation is perturbed, JBP1 binding is dramatically reduced.(Chemical Equation Presented).

KW - DNA

KW - Glycosides

KW - Molecular dynamics

KW - Molecular recognition

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SN - 1433-7851

VL - 46

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EP - 2843

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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ER -

O-glycoside orientation is an essential aspect of base J recognition by the kinetoplastid DNA-binding protein JBP1

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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