Of rodents and ruminants: A comparison of small noncoding RNA requirements in mouse and bovine reproduction

Lauren G. Chukrallah, Aditi Badrinath, Kelly Seltzer, Elizabeth M. Snyder

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Ruminants are major producers of meat and milk, thus managing their reproductive potential is a key element in costeffective, safe, and efficient food production. Of particular concern, defects in male germ cells and female germ cells may lead to significantly reduced live births relative to fertilization. However, the underlying molecular drivers of these defects are unclear. Small noncoding RNAs, such as piRNAs and miRNAs, are known to be important regulators of germcell physiology in mouse (the best-studied mammalian model organism) and emerging evidence suggests that this is also the case in a range of ruminant species, in particular bovine. Similarities exist between mouse and bovids, especially in the case of meiotic and postmeiotic male germ cells. However, fundamental differences in small RNA abundance and metabolism between these species have been observed in the female germ cell, differences that likely have profound impacts on their physiology. Further, parentally derived small noncoding RNAs are known to influence early embryos and significant species-specific differences in germ-cell born small noncoding RNAs have been observed. These findings demonstrate the mouse to be an imperfect model for understanding germ-cell small noncoding RNA biology in ruminants and highlight the need to increase research efforts in this underappreciated aspect of animal reproduction.

Original languageEnglish (US)
Article numberskaa388
JournalJournal of animal science
Issue number3
StatePublished - Mar 1 2021

All Science Journal Classification (ASJC) codes

  • Food Science
  • Animal Science and Zoology
  • Genetics


  • PIWI-interacting RNAs
  • bovids
  • bovine
  • mice
  • microRNAs
  • ruminants


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