TY - JOUR
T1 - Omics Analyses of Gut Microbiota in a Circadian Rhythm Disorder Mouse Model Fed with Oolong Tea Polyphenols
AU - Guo, Tongtong
AU - Song, Dan
AU - Ho, Chi Tang
AU - Zhang, Xin
AU - Zhang, Chundan
AU - Cao, Jinxuan
AU - Wu, Zufang
N1 - Funding Information:
This work was sponsored by Zhejiang Provincial Natural Science Foundation of China (LY19C200006), the Key Research and Development Project of Zhejiang Province (2017C02039 and 2018C02047), and K. C. Wong Magna Fund in Ningbo University.
Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/8/14
Y1 - 2019/8/14
N2 - Microbiome has been revealed as a key element involved in maintaining the circadian rhythms. Oolong tea polyphenols (OTP) has been shown to have potential prebiotic activity. Therefore, this study focused on the regulation mechanisms of OTP on host circadian rhythms. After 8 weeks of OTP administration, a large expansion in the relative abundance of Bacteroidetes with a decrease in Firmicutes was observed, which reflected the positive modulatory effect of OTP on gut flora. In addition, Kyoto Encyclopedia of Genes and Genomes pathways of ATP-binding cassette transporters, two-component system, and the biosynthesis of amino acids enriched the most differentially expressed genes after OTP treatment. Of the differentially expressed proteins identified, most were related to metabolism, genetic information processing, and environmental information processing. It underscores the ability of OTP to regulate circadian rhythm by enhancing beneficial intestinal microbiota and affecting metabolic pathways, contributing to the improvement of host microecology.
AB - Microbiome has been revealed as a key element involved in maintaining the circadian rhythms. Oolong tea polyphenols (OTP) has been shown to have potential prebiotic activity. Therefore, this study focused on the regulation mechanisms of OTP on host circadian rhythms. After 8 weeks of OTP administration, a large expansion in the relative abundance of Bacteroidetes with a decrease in Firmicutes was observed, which reflected the positive modulatory effect of OTP on gut flora. In addition, Kyoto Encyclopedia of Genes and Genomes pathways of ATP-binding cassette transporters, two-component system, and the biosynthesis of amino acids enriched the most differentially expressed genes after OTP treatment. Of the differentially expressed proteins identified, most were related to metabolism, genetic information processing, and environmental information processing. It underscores the ability of OTP to regulate circadian rhythm by enhancing beneficial intestinal microbiota and affecting metabolic pathways, contributing to the improvement of host microecology.
KW - circadian clock
KW - intestinal microbiota
KW - modulatory effect
KW - oolong tea polyphenols
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U2 - 10.1021/acs.jafc.9b03000
DO - 10.1021/acs.jafc.9b03000
M3 - Article
C2 - 31328515
AN - SCOPUS:85071354986
SN - 0021-8561
VL - 67
SP - 8847
EP - 8854
JO - Journal of agricultural and food chemistry
JF - Journal of agricultural and food chemistry
IS - 32
ER -