On the measurement of human osteosarcoma cell elastic modulus using shear assay experiments

Yifang Cao, Randy Bly, Will Moore, Zhan Gao, Alberto M. Cuitino, Wole Soboyejo

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

This paper presents a method for determining the elastic modulus of human osteosarcoma (HOS) cells. The method involves a combination of shear assay experiments and finite element analysis. Following in-situ observations of cell deformation during shear assay experiments, a digital image correlation (DIC) technique was used to determine the local displacement and strain fields. Finite element analysis was then used to determine the Young's moduli of HOS cells. This involved a match of the maximum shear stresses estimated from the experimental shear assay measurements and those calculated from finite element simulations.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalJournal of Materials Science: Materials in Medicine
Volume18
Issue number1
DOIs
StatePublished - Jan 2007

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Fingerprint

Dive into the research topics of 'On the measurement of human osteosarcoma cell elastic modulus using shear assay experiments'. Together they form a unique fingerprint.

Cite this