One-flask syntheses of c-di-GMP and the [ R p, R p] and [ R p, S p] thiophosphate analogues

Barbara L. Gaffney, Elizabeth Veliath, Jianwei Zhao, Roger A. Jones

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

(Figure Presented) An integrated set of reactions and conditions that allow an eight-step one-flask synthesis of the protected derivatives of c-di-GMP and the [Rp,Rp] and [Rp,Sp] thiophosphate analogues is reported. Deprotection is also carried out as a one-flask procedure, with the final products isolated by crystallization from the reaction mixture. Chromatography is only used for separation of the thiophosphate diastereomers.

Original languageEnglish (US)
Pages (from-to)3269-3271
Number of pages3
JournalOrganic letters
Volume12
Issue number14
DOIs
StatePublished - Jul 16 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'One-flask syntheses of c-di-GMP and the [ R p, R p] and [ R p, S p] thiophosphate analogues'. Together they form a unique fingerprint.

Cite this