Abstract
(Figure Presented) An integrated set of reactions and conditions that allow an eight-step one-flask synthesis of the protected derivatives of c-di-GMP and the [Rp,Rp] and [Rp,Sp] thiophosphate analogues is reported. Deprotection is also carried out as a one-flask procedure, with the final products isolated by crystallization from the reaction mixture. Chromatography is only used for separation of the thiophosphate diastereomers.
Original language | English (US) |
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Pages (from-to) | 3269-3271 |
Number of pages | 3 |
Journal | Organic letters |
Volume | 12 |
Issue number | 14 |
DOIs | |
State | Published - Jul 16 2010 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry