Oolong Tea Polyphenols Ameliorate Circadian Rhythm of Intestinal Microbiome and Liver Clock Genes in Mouse Model

Tongtong Guo; Chi Tang Ho; Xin Zhang; Jinxuan Cao; Hongfei Wang; Xingfeng Shao; Daodong Pan; Zufang Wu

doi:10.1021/acs.jafc.9b04869

Oolong Tea Polyphenols Ameliorate Circadian Rhythm of Intestinal Microbiome and Liver Clock Genes in Mouse Model

Tongtong Guo, Chi Tang Ho, Xin Zhang, Jinxuan Cao, Hongfei Wang, Xingfeng Shao, Daodong Pan, Zufang Wu

School of Environmental and Biological Sciences, Food Science

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Our present study focused on the regulating effect of oolong tea polyphenols (OTPs) on the circadian rhythm of liver and intestinal microbiome. OTP significantly alleviated the disrupted diurnal oscillation and phase shift of the specific intestinal microbiota and liver clock genes in mice induced by constant dark (CD) treatment. Transcriptomics revealed that 1114 genes in the control group and 647 genes in the CD group showed circadian rhythm while 723 genes were rhythmic in the CD-OTP group. The Gene Ontology (GO) database provided significant differences in differentially expressed genes (DEGs) in response to OTP treatment. In addition, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enriched the most DEGs after OTP intervention including "Focal adhesion" (9 DEGs) and "PI3K-Akt signaling pathway" (9 DEGs). The present study provided a global view that OTP may alleviate the circadian rhythm disorder of the host, contributing to the improvement of microecology and health.

Original language	English (US)
Journal	Journal of agricultural and food chemistry
DOIs	https://doi.org/10.1021/acs.jafc.9b04869
State	Accepted/In press - 2019

All Science Journal Classification (ASJC) codes

Chemistry(all)
Agricultural and Biological Sciences(all)

Keywords

circadian clock
intestinal microbiome
oolong tea polyphenols
regulation mechanism

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10.1021/acs.jafc.9b04869

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title = "Oolong Tea Polyphenols Ameliorate Circadian Rhythm of Intestinal Microbiome and Liver Clock Genes in Mouse Model",

abstract = "Our present study focused on the regulating effect of oolong tea polyphenols (OTPs) on the circadian rhythm of liver and intestinal microbiome. OTP significantly alleviated the disrupted diurnal oscillation and phase shift of the specific intestinal microbiota and liver clock genes in mice induced by constant dark (CD) treatment. Transcriptomics revealed that 1114 genes in the control group and 647 genes in the CD group showed circadian rhythm while 723 genes were rhythmic in the CD-OTP group. The Gene Ontology (GO) database provided significant differences in differentially expressed genes (DEGs) in response to OTP treatment. In addition, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enriched the most DEGs after OTP intervention including {"}Focal adhesion{"} (9 DEGs) and {"}PI3K-Akt signaling pathway{"} (9 DEGs). The present study provided a global view that OTP may alleviate the circadian rhythm disorder of the host, contributing to the improvement of microecology and health.",

keywords = "circadian clock, intestinal microbiome, oolong tea polyphenols, regulation mechanism",

author = "Tongtong Guo and Ho, {Chi Tang} and Xin Zhang and Jinxuan Cao and Hongfei Wang and Xingfeng Shao and Daodong Pan and Zufang Wu",

note = "Funding Information: This work was sponsored by the Zhejiang Provincial Natural Science Foundation of China (LY19C200006), the Key Research and Development Project of Zhejiang Province (2017C02039 and 2018C02047), the Scientific Research Foundation of Graduate School of Ningbo University, and the K. C. Wong Magna Fund in Ningbo University. Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

doi = "10.1021/acs.jafc.9b04869",

language = "English (US)",

journal = "Journal of Agricultural and Food Chemistry",

issn = "0021-8561",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Oolong Tea Polyphenols Ameliorate Circadian Rhythm of Intestinal Microbiome and Liver Clock Genes in Mouse Model

AU - Guo, Tongtong

AU - Ho, Chi Tang

AU - Zhang, Xin

AU - Cao, Jinxuan

AU - Wang, Hongfei

AU - Shao, Xingfeng

AU - Pan, Daodong

AU - Wu, Zufang

N1 - Funding Information: This work was sponsored by the Zhejiang Provincial Natural Science Foundation of China (LY19C200006), the Key Research and Development Project of Zhejiang Province (2017C02039 and 2018C02047), the Scientific Research Foundation of Graduate School of Ningbo University, and the K. C. Wong Magna Fund in Ningbo University. Publisher Copyright: © 2019 American Chemical Society.

PY - 2019

Y1 - 2019

N2 - Our present study focused on the regulating effect of oolong tea polyphenols (OTPs) on the circadian rhythm of liver and intestinal microbiome. OTP significantly alleviated the disrupted diurnal oscillation and phase shift of the specific intestinal microbiota and liver clock genes in mice induced by constant dark (CD) treatment. Transcriptomics revealed that 1114 genes in the control group and 647 genes in the CD group showed circadian rhythm while 723 genes were rhythmic in the CD-OTP group. The Gene Ontology (GO) database provided significant differences in differentially expressed genes (DEGs) in response to OTP treatment. In addition, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enriched the most DEGs after OTP intervention including "Focal adhesion" (9 DEGs) and "PI3K-Akt signaling pathway" (9 DEGs). The present study provided a global view that OTP may alleviate the circadian rhythm disorder of the host, contributing to the improvement of microecology and health.

AB - Our present study focused on the regulating effect of oolong tea polyphenols (OTPs) on the circadian rhythm of liver and intestinal microbiome. OTP significantly alleviated the disrupted diurnal oscillation and phase shift of the specific intestinal microbiota and liver clock genes in mice induced by constant dark (CD) treatment. Transcriptomics revealed that 1114 genes in the control group and 647 genes in the CD group showed circadian rhythm while 723 genes were rhythmic in the CD-OTP group. The Gene Ontology (GO) database provided significant differences in differentially expressed genes (DEGs) in response to OTP treatment. In addition, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enriched the most DEGs after OTP intervention including "Focal adhesion" (9 DEGs) and "PI3K-Akt signaling pathway" (9 DEGs). The present study provided a global view that OTP may alleviate the circadian rhythm disorder of the host, contributing to the improvement of microecology and health.

KW - circadian clock

KW - intestinal microbiome

KW - oolong tea polyphenols

KW - regulation mechanism

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Oolong Tea Polyphenols Ameliorate Circadian Rhythm of Intestinal Microbiome and Liver Clock Genes in Mouse Model

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