Open-label, phase 2 study of blinatumomab after frontline R-chemotherapy in adults with newly diagnosed, high-risk DLBCL

Deborah A. Katz, Joan D. Morris, Michael P. Chu, Kevin A. David, Catherine Thieblemont, Nicholas J. Morley, Sharif S. Khan, Andreas Viardot, Alejandro Martín García-Sancho, Guillermo Rodríguez-García, Mariana Bastos-Oreiro, Seung Tae Lee, William Kormany, Yuqi Chen, Hansen L. Wong, Abraham A. Anderson, Yuliya Katlinskaya, Ariel A. Avilion, Tian Dai, Eva González-Barca

    Research output: Contribution to journalArticlepeer-review

    7 Scopus citations

    Abstract

    This open-label, multicenter, single-arm, phase 2 study assessed the safety and efficacy of blinatumomab consolidation therapy in adult patients with newly diagnosed, high-risk diffuse large B-cell lymphoma (DLBCL; International Prognostic Index 3–5 and/or double-/triple-hit or double MYC/BCL-2 expressors) who achieved complete response (CR), partial response (PR), or stable disease (SD) following run-in with 6 cycles of R-chemotherapy (NCT03023878). Of the 47 patients enrolled, 28 received blinatumomab. Five patients (17.9%) experienced grade 4 treatment-emergent adverse events of interest (neutropenia, n = 4; infection, n = 1). Two deaths reported at the end of the study were unrelated to treatment with blinatumomab (disease progression, n = 1; infection, n = 1). 3/4 patients with PR and 4/4 patients with SD after R-chemotherapy achieved CR following blinatumomab. Consolidation with blinatumomab in patients with newly diagnosed, high-risk DLBCL who did not progress under R-chemotherapy was better tolerated than in previous studies where blinatumomab was used for treatment of patients with lymphoma.

    Original languageEnglish (US)
    Pages (from-to)2063-2073
    Number of pages11
    JournalLeukemia and Lymphoma
    Volume63
    Issue number9
    DOIs
    StatePublished - 2022

    All Science Journal Classification (ASJC) codes

    • Hematology
    • Oncology
    • Cancer Research

    Keywords

    • Relapsed/refractory
    • blinatumomab
    • high-risk DLBCL

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