Opioid antagonist naltrexone disrupts feedback interaction between μ and δ opioid receptors in splenocytes to prevent alcohol inhibition of NK cell function

Nadka I. Boyadjieva, Kirti Chaturvedi, Michael M. Poplawski, Dipak K. Sarkar

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Naltrexone, an opioid antagonist, has been used in clinical trials to treat alcoholism. As the opioid peptides β-endorphin and enkephalin increase splenic NK cell function in laboratory animals, it is anticipated that naltrexone treatment will cause immunosuppression. However, we report in this study that chronic naltrexone administration in laboratory rats increases the cytolytic activity of NK cells. It also prevents alcohol's suppressive effect on these cells. We identified that, in the splenocytes, δ opioid receptor expression is tightly controlled by negative feedback regulation of μ opioid receptors. Naltrexone disrupts this feedback control by reducing μ opioid receptor function, thereby up-regulating δ opioid receptor binding, which results in an enhanced NK cell cytolytic response to δ opioid receptor ligands. We conclude that naitrexone, which has been shown to be a promising agent for the clinical management of alcoholism, may have potential use in the treatment of immune deficiency in alcoholic and nonalcoholic patients.

Original languageEnglish (US)
Pages (from-to)42-49
Number of pages8
JournalJournal of Immunology
Volume173
Issue number1
DOIs
StatePublished - Jul 1 2004

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Opioid antagonist naltrexone disrupts feedback interaction between μ and δ opioid receptors in splenocytes to prevent alcohol inhibition of NK cell function'. Together they form a unique fingerprint.

Cite this