Optimal path to epigenetic switching

David Marin Roma, Ruadhan A. O'Flanagan, Andrei E. Ruckenstein, Anirvan Sengupta, Ranjan Mukhopadhyay

Research output: Contribution to journalArticle

56 Scopus citations


We use large deviation methods to calculate rates of noise-induced transitions between states in multistage genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation.

Original languageEnglish (US)
Article number011902
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Issue number1
StatePublished - Jan 2005

All Science Journal Classification (ASJC) codes

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

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