Optimal path to epigenetic switching

David Marin Roma, Ruadhan A. O'Flanagan, Andrei E. Ruckenstein, Anirvan Sengupta, Ranjan Mukhopadhyay

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

We use large deviation methods to calculate rates of noise-induced transitions between states in multistage genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation.

Original languageEnglish (US)
Article number011902
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume71
Issue number1
DOIs
StatePublished - Jan 1 2005

Fingerprint

Noise-induced Transition
Genetic Network
Optimal Path
Master Equation
Large Deviations
Switch
switches
Numerical Solution
deviation
Calculate

All Science Journal Classification (ASJC) codes

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

Cite this

Roma, David Marin ; O'Flanagan, Ruadhan A. ; Ruckenstein, Andrei E. ; Sengupta, Anirvan ; Mukhopadhyay, Ranjan. / Optimal path to epigenetic switching. In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 2005 ; Vol. 71, No. 1.
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Optimal path to epigenetic switching. / Roma, David Marin; O'Flanagan, Ruadhan A.; Ruckenstein, Andrei E.; Sengupta, Anirvan; Mukhopadhyay, Ranjan.

In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, Vol. 71, No. 1, 011902, 01.01.2005.

Research output: Contribution to journalArticle

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