Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X 7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535

Allen J. Duplantier, Mark A. Dombroski, Chakrapani Subramanyam, Aimee M. Beaulieu, Shang Poa Chang, Christopher A. Gabel, Crystal Jordan, Amit S. Kalgutkar, Kenneth G. Kraus, Jeff M. Labasi, Christopher Mussari, David G. Perregaux, Rick Shepard, Timothy J. Taylor, Kristen A. Trevena, Carrie Whitney-Pickett, Kwansik Yoon

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

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Chemical Compounds