Organization of soluble enzymes in the cell Relay at the surface

Research output: Contribution to journalArticle

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Abstract

A model is proposed uniting two groups of facts: The adsorption of enzymes on subcellular structures and the direct ('from hand to hand') transfer of metabolites between enzymes. The basic idea is that the binding of metabolites (substrates and/or products) results in desorption of the enzymes from subcellular structures during each catalytic act. This makes the enzymes mobile and capable of directly (from hand to hand) transferring metabolites to other enzymes adsorbed on subcellular structures. The model leads to a mechanism by means of which soluble enzymes can be compartmentalized in defined regions of the cytoplasm.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalFEBS Letters
Volume237
Issue number1-2
DOIs
StatePublished - Sep 12 1988
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Keywords

  • Enzyme compartmentation
  • Intracellular organization
  • Metabolite transfer
  • Supramolecular enzyme organization

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