@article{90297126ebe44696a987bb7783e8574e,
title = "Origins and mechanisms leading to aneuploidy in human eggs",
abstract = "The gain or loss of a chromosome—or aneuploidy—acts as one of the major triggers for infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than 40% of eggs in women at both ends of the age spectrum, that is, young girls as well as women of advancing maternal age. Recent studies in human oocytes and embryos using genomics, cytogenetics, and in silico modeling all provide new insight into the rates and potential genetic and cellular factors associated with aneuploidy at varying stages of development. Here, we review recent studies that are shedding light on potential molecular mechanisms of chromosome missegregation in oocytes and embryos across the entire female reproductive life span.",
author = "Lena Wartosch and Karen Schindler and Melina Schuh and Gruhn, {Jennifer R.} and Hoffmann, {Eva R.} and McCoy, {Rajiv C.} and Jinchuan Xing",
note = "Funding Information: The authors are part of the Origins of Aneuploidy Consortium and thank all of the other members for discussion and funding. J. Xing and K. Schindler were funded by a grant from the NIH/NICHD (R01‐HD091331). E. R. Hoffmann and J. Gruhn were funded by NNF Young Investigator Award (NNF15OC0016662), ERC Consolidator Grant (724718‐ReCAP), and support from the DNRF Center Grant (DNRF115). RCM was funded by the NIH/NIGMS (R35GM133747). L. Wartosch and M. Schuh were funded by the Max Planck Society and Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy—EXC 2067/1‐ 390729940 and Leibniz Prize (SCHU 3047/1‐1) to M. Schuh. The author list was generated at random and all authors contributed equally. Publisher Copyright: {\textcopyright} 2021 The Authors. Prenatal Diagnosis published by John Wiley & Sons Ltd.",
year = "2021",
month = apr,
doi = "10.1002/pd.5927",
language = "English (US)",
volume = "41",
pages = "620--630",
journal = "Prenatal Diagnosis",
issn = "0197-3851",
publisher = "John Wiley and Sons Ltd",
number = "5",
}