Orotate uptake and metabolism in normal and neoplastic tissues

Michael A. Lea, Virginia Oliphant, Aleykutty Luke

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


1. 1. The uptake of [3H]orotate was greater in mouse liver than in hepatoma but the difference was less marked than in the rat. 2. 2. Of the tissues examined, a high uptake of [3H]orotate was restricted to the liver and kidney in rat, mouse and guinea-pig. 3. 3. We confirmed that a high orotate diet greatly increases the ratio of UTP to ATP concentration in rat liver but we observed that there is little change of this nucleotide ratio in kidney. 4. 4. Evidence was obtained for a different pattern of orotate metabolism in rat liver and kidney.

Original languageEnglish (US)
Pages (from-to)581-586
Number of pages6
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Issue number3
StatePublished - 1987

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology

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