Orthobiologics in foot and ankle surgery

Sheldon S. Lin, Nicholas J. Montemurro, Ethan S. Krell

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Exploration into the molecular aspects of the healing process has led to the development of autologous and recombinant biologic agents. These products, collectively known as orthobiologics, have the potential to optimize favorable outcomes with respect to bone and soft-tissue restoration and to maximize the natural healing response. These orthobiologics include platelet-derived growth factor, bone morphogenetic proteins, and platelet-rich plasma. Although the usefulness of these growth factors is well described in various fields of surgery, few data exist to support or oppose the specific application of growth factors in foot and ankle surgery.

Original languageEnglish (US)
Pages (from-to)113-122
Number of pages10
JournalJournal of the American Academy of Orthopaedic Surgeons
Issue number2
StatePublished - Feb 1 2016

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine


  • bone morphogenetic proteins (BMPs)
  • foot and ankle
  • orthobiologics
  • platelet-derived growth factor (PDGF)
  • platelet-rich plasma (PRP)


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