Outer nuclear membrane fusion of adjacent nuclei in varicella-zoster virus-induced syncytia

Wei Wang, Lianwei Yang, Xiumin Huang, Wenkun Fu, Dequan Pan, Linli Cai, Jianghui Ye, Jian Liu, Ningshao Xia, Tong Cheng, Hua Zhu

Research output: Contribution to journalArticle

Abstract

Syncytia formation has been considered important for cell-to-cell spread and pathogenesis of many viruses. As a syncytium forms, individual nuclei often congregate together, allowing close contact of nuclear membranes and possibly fusion to occur. However, there is currently no reported evidence of nuclear membrane fusion between adjacent nuclei in wild-type virus-induced syncytia. Varicella-zoster virus (VZV) is one typical syncytia-inducing virus that causes chickenpox and shingles in humans. Here, we report, for the first time, an interesting observation of apparent fusion of the outer nuclear membranes from juxtaposed nuclei that comprise VZV syncytia both in ARPE-19 human epithelial cells in vitro and in human skin xenografts in the SCID-hu mouse model in vivo. This work reveals a novel aspect of VZV-related cytopathic effect in the context of multinucleated syncytia. Additionally, the information provided by this study could be helpful for future studies on interactions of viruses with host cell nuclei.

Original languageEnglish (US)
Pages (from-to)34-38
Number of pages5
JournalVirology
Volume512
DOIs
StatePublished - Dec 1 2017

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Nuclear Fusion
Membrane Fusion
Human Herpesvirus 3
Nuclear Envelope
Giant Cells
Viruses
SCID Mice
Herpes Zoster
Cell Nucleus
Heterografts
Epithelial Cells
Observation
Skin

All Science Journal Classification (ASJC) codes

  • Virology

Cite this

Wang, Wei ; Yang, Lianwei ; Huang, Xiumin ; Fu, Wenkun ; Pan, Dequan ; Cai, Linli ; Ye, Jianghui ; Liu, Jian ; Xia, Ningshao ; Cheng, Tong ; Zhu, Hua. / Outer nuclear membrane fusion of adjacent nuclei in varicella-zoster virus-induced syncytia. In: Virology. 2017 ; Vol. 512. pp. 34-38.
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abstract = "Syncytia formation has been considered important for cell-to-cell spread and pathogenesis of many viruses. As a syncytium forms, individual nuclei often congregate together, allowing close contact of nuclear membranes and possibly fusion to occur. However, there is currently no reported evidence of nuclear membrane fusion between adjacent nuclei in wild-type virus-induced syncytia. Varicella-zoster virus (VZV) is one typical syncytia-inducing virus that causes chickenpox and shingles in humans. Here, we report, for the first time, an interesting observation of apparent fusion of the outer nuclear membranes from juxtaposed nuclei that comprise VZV syncytia both in ARPE-19 human epithelial cells in vitro and in human skin xenografts in the SCID-hu mouse model in vivo. This work reveals a novel aspect of VZV-related cytopathic effect in the context of multinucleated syncytia. Additionally, the information provided by this study could be helpful for future studies on interactions of viruses with host cell nuclei.",
author = "Wei Wang and Lianwei Yang and Xiumin Huang and Wenkun Fu and Dequan Pan and Linli Cai and Jianghui Ye and Jian Liu and Ningshao Xia and Tong Cheng and Hua Zhu",
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Wang, W, Yang, L, Huang, X, Fu, W, Pan, D, Cai, L, Ye, J, Liu, J, Xia, N, Cheng, T & Zhu, H 2017, 'Outer nuclear membrane fusion of adjacent nuclei in varicella-zoster virus-induced syncytia', Virology, vol. 512, pp. 34-38. https://doi.org/10.1016/j.virol.2017.09.002

Outer nuclear membrane fusion of adjacent nuclei in varicella-zoster virus-induced syncytia. / Wang, Wei; Yang, Lianwei; Huang, Xiumin; Fu, Wenkun; Pan, Dequan; Cai, Linli; Ye, Jianghui; Liu, Jian; Xia, Ningshao; Cheng, Tong; Zhu, Hua.

In: Virology, Vol. 512, 01.12.2017, p. 34-38.

Research output: Contribution to journalArticle

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T1 - Outer nuclear membrane fusion of adjacent nuclei in varicella-zoster virus-induced syncytia

AU - Wang, Wei

AU - Yang, Lianwei

AU - Huang, Xiumin

AU - Fu, Wenkun

AU - Pan, Dequan

AU - Cai, Linli

AU - Ye, Jianghui

AU - Liu, Jian

AU - Xia, Ningshao

AU - Cheng, Tong

AU - Zhu, Hua

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Syncytia formation has been considered important for cell-to-cell spread and pathogenesis of many viruses. As a syncytium forms, individual nuclei often congregate together, allowing close contact of nuclear membranes and possibly fusion to occur. However, there is currently no reported evidence of nuclear membrane fusion between adjacent nuclei in wild-type virus-induced syncytia. Varicella-zoster virus (VZV) is one typical syncytia-inducing virus that causes chickenpox and shingles in humans. Here, we report, for the first time, an interesting observation of apparent fusion of the outer nuclear membranes from juxtaposed nuclei that comprise VZV syncytia both in ARPE-19 human epithelial cells in vitro and in human skin xenografts in the SCID-hu mouse model in vivo. This work reveals a novel aspect of VZV-related cytopathic effect in the context of multinucleated syncytia. Additionally, the information provided by this study could be helpful for future studies on interactions of viruses with host cell nuclei.

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