TY - JOUR
T1 - Ovarian Cancer in Women of African Ancestry (OCWAA) consortium
T2 - a resource of harmonized data from eight epidemiologic studies of African American and white women
AU - Schildkraut, Joellen M.
AU - Peres, Lauren C.
AU - Bethea, Traci N.
AU - Camacho, Fabian
AU - Chyn, Deanna
AU - Cloyd, Emily K.
AU - Bandera, Elisa V.
AU - Beeghly-Fadiel, Alicia
AU - Lipworth, Loren
AU - Joslin, Charlotte E.
AU - Davis, Faith G.
AU - Moorman, Patricia G.
AU - Myers, Evan
AU - Ochs-Balcom, Heather M.
AU - Setiawan, Veronica Wendy
AU - Pike, Malcolm C.
AU - Wu, Anna H.
AU - Rosenberg, Lynn
N1 - Funding Information:
Funding This project is supported by grant R01-CA207260 (L.A. Rosenberg, J.M. Schildkraut) from the National Cancer Institute (NCI), National Institutes of Health (NIH), U.S. Department of Health and Human Services. In addition, AACES was funded by NCI (R01-CA142081; J.M. Schildkraut); BWHS is funded by NIH (R01-CA058420 and UM1CA164974); CCCCS was funded by NIH/ NCI (R01-CA61093; K.A. Rosenblatt); LACOCS was funded by NCI (R01-CA17054 [Pike], R01-CA58598 [Goodman, A. Wu] and Cancer Center Core Grant P30-CA014089 [Henderson, A. Wu]) and the California Cancer Research Program (2II0200 [A. Wu]); and NCOCS was funded by NCI (R01-CA076016; J.M. Schildkraut). SCCS is supported by the NCI (Grants R01-CA092447 and U01-CA202979; W.J. Blot and W. Zheng), and data collection is performed by the Survey and Biospecimen Shared Resource, which is supported by the Vanderbilt-Ingram Cancer Center (P30-CA68485). In addition, support to bring SCCS to OCWAA was provided by a Pilot Award (PI: Beeghly-Fadiel) from the NIH Precision Medicine and Health Disparities Collaborative (NIMHD/NHGRI U54-MD010722). The WHI program is funded by the National Heart, Lung, and Blood Institute, NIH through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C. Additionally, WHI, “The women’s health Initiative Cancer Survivor Cohort,” is funded by NCI (5UM1CA173642-05; G.L. Anderson).
Funding Information:
The authors thank the WHI investigators and staff for their dedication and the study participants for making the program possible. A full listing of WHI investigators can be found at: http://www.whi.org/researchers/Documents%20%20Write%20a%20Paper/WHI%20Investigator%20Long%20List.pdf. The authors would also like to thank Alpana Kaushiva for harmonizing the data from the Cook County Case?Control Study. Additionally, the authors sincerely thank the state cancer registries that contributed to the OCWAA studies: Arizona, Arkansas, California, Colorado, Connecticut, Delaware, District of Columbia, Florida, Georgia, Hawaii, Illinois, Indiana, Kentucky, Louisiana, Maryland, Massachusetts, Michigan, Mississippi, New Jersey, New York, North Carolina, Oklahoma, Pennsylvania, South Carolina, Tennessee, Texas, Virginia, and West Virginia.
Publisher Copyright:
© 2019, Springer Nature Switzerland AG.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Purpose: Although the incidence rate of epithelial ovarian cancer (EOC) is somewhat lower in African American (AA) than white women, survival is worse. The Ovarian Cancer in Women of African Ancestry (OCWAA) consortium will overcome small, study-specific sample sizes to better understand racial differences in EOC risk and outcomes. Methods: We harmonized risk factors and prognostic characteristics from eight U.S. studies: the North Carolina Ovarian Cancer Study (NCOCS), the Los Angeles County Ovarian Cancer Study (LACOCS), the African American Cancer Epidemiology Study (AACES), the Cook County Case–Control Study (CCCCS), the Black Women’s Health Study (BWHS), the Women’s Health Initiative (WHI), the Multiethnic Cohort Study (MEC), and the Southern Community Cohort Study (SCCS). Results: Determinants of disparities for risk and survival in 1,146 AA EOC cases and 2,922 AA controls will be compared to 3,368 white EOC cases and 10,270 white controls. Analyses include estimation of population-attributable risk percent (PAR%) by race. Conclusion: OCWAA is uniquely positioned to study the epidemiology of EOC in AA women compared with white women to address disparities. Studies of EOC have been underpowered to address factors that may explain AA-white differences in the incidence and survival. OCWAA promises to provide novel insight into disparities in ovarian cancer.
AB - Purpose: Although the incidence rate of epithelial ovarian cancer (EOC) is somewhat lower in African American (AA) than white women, survival is worse. The Ovarian Cancer in Women of African Ancestry (OCWAA) consortium will overcome small, study-specific sample sizes to better understand racial differences in EOC risk and outcomes. Methods: We harmonized risk factors and prognostic characteristics from eight U.S. studies: the North Carolina Ovarian Cancer Study (NCOCS), the Los Angeles County Ovarian Cancer Study (LACOCS), the African American Cancer Epidemiology Study (AACES), the Cook County Case–Control Study (CCCCS), the Black Women’s Health Study (BWHS), the Women’s Health Initiative (WHI), the Multiethnic Cohort Study (MEC), and the Southern Community Cohort Study (SCCS). Results: Determinants of disparities for risk and survival in 1,146 AA EOC cases and 2,922 AA controls will be compared to 3,368 white EOC cases and 10,270 white controls. Analyses include estimation of population-attributable risk percent (PAR%) by race. Conclusion: OCWAA is uniquely positioned to study the epidemiology of EOC in AA women compared with white women to address disparities. Studies of EOC have been underpowered to address factors that may explain AA-white differences in the incidence and survival. OCWAA promises to provide novel insight into disparities in ovarian cancer.
KW - Disparities
KW - Ovarian cancer
KW - Race
KW - Risk
KW - Survival
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UR - http://www.scopus.com/inward/citedby.url?scp=85068148875&partnerID=8YFLogxK
U2 - 10.1007/s10552-019-01199-7
DO - 10.1007/s10552-019-01199-7
M3 - Article
C2 - 31236792
AN - SCOPUS:85068148875
SN - 0957-5243
VL - 30
SP - 967
EP - 978
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 9
ER -