Overcoming drug resistance by phytochemicals

Marion M. Chan, Dunne Fong

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Abstract

Cancer drug resistance is a major cause of treatment failure. Various cancer chemopreventive phytochemicals can sensitize chemoresistant and radioresistant cancer cells. From in vitro tissue culture and in vivo xenograft studies with drug-resistant human cancer cell lines, synergistic effects have been shown between cancer therapeutics and molecules isolated from the spice turmeric, the beverages such as green tea and red wine, other sources of dietary fruits, vegetables, and grains, as well as herbal medicine. However, concerns on safety and bio-accessibility must be addressed further, and the proof-of-concept clinical data, to date, are still missing.

Original languageEnglish (US)
Title of host publicationDrug Resistance in Cancer Cells
PublisherSpringer US
Pages315-342
Number of pages28
ISBN (Print)9780387894447
DOIs
StatePublished - 2009

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • General Biochemistry, Genetics and Molecular Biology

Keywords

  • Cancer prevention
  • Cancer stem cells
  • Combination therapy
  • Curcumin
  • Epigallocatechin gallate
  • Phytochemicals
  • Resveratrol
  • Synergy

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